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United States

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Cat. No.: HY-167671

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BE-10988

BE-10988 is a DNA topoisomerase inhibitor. BE-10988 inhibits the growth of Doxorubicin (HY-15142A)-resistant and vincristine-resistant P388 mouse leukemia cell lines by increasing the formation of DNA topoisomerase complexes.

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CAS No.: 135261-89-1
화학식: C₁₃H₁₀N₄O₃S
분자량:302.31

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

BE-10988 Chemical Structure

CAS No.: 135261-89-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-BR-3	IC₅₀	8.7 μM Compound: 1	The IC50 value was measured on human breast cancer cell line SK-BR-3. The IC50 value was measured on human breast cancer cell line SK-BR-3.	[PMID: 7699696]
V79	IC₅₀	5.1 μM Compound: 1	The IC50 value was measured on V79 cells in the presence of nitrogen using MTT assay. The IC50 value was measured on V79 cells in the presence of nitrogen using MTT assay.	[PMID: 7699696]
V79	IC₅₀	6.2 μM Compound: 1	The IC50 value was measured on V79 cells in the presence of air using MTT assay. The IC50 value was measured on V79 cells in the presence of air using MTT assay.	[PMID: 7699696]

Chemical Information

CAS No. 135261-89-1
분자량 302.31
화학식 C₁₃H₁₀N₄O₃S
SMILES

O=C(C1=CSC(C2=CN(C)C(C(C=C3N)=O)=C2C3=O)=N1)N
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
- Microorganism
Actinomycetes
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Oka H, et al. A NEW TOPOISOMERASE-II INHIBITOR, BE-10988, PRODUCED BY A STREPTOMYCETE I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION[J]. The Journal of Antibiotics, 1991, 44(5): 486-491. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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