BJH-86
BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC50 = 5 μM). BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC50 >10 μM). BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 3067849-10-6
- 화학식: C23H21N3O2
- 분자량:371.43
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
PDE10A |
In Vitro
BJH-86 (1-10 μM, 30 min-96 h) potently inhibits mitochondrial complex I (oxygen consumption rate inhibition IC50 = 5 μM) in A549 human lung cancer cells and EO771 murine breast cancer cells[1].
BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A, IC50 >10 μM) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57Bl6 mice bearing EO771 xenografts[1]
-
Dosage:2 mg/kg single dose 1 h before radiotherapy and 30 mg/kg repeated administration
-
Administration:Intravenously injection
-
Result:Reduced tumor hypoxia.
Enhanced radiosensitivity (5 Gy) .
Prolonged tumor growth delay from 2 days to 4 days.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
-
CAS No. 3067849-10-6
-
분자량 371.43
-
화학식 C23H21N3O2
-
SMILES
COC1=CC=C2N=CC=C(CC3=CC=CC(C4=CN(C5COC5)N=C4)=C3)C2=C1
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BJH-86 Related Classifications
HY-178987 Related Classifications
Powered by Bioz