BPH-675
BPH-675 is a large bisphosphonate inhibitor with long hydrophobic side chains and a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor with an IC50 of 0.71 μM. GGPPS inhibitor promotes HUVEC apoptosis.
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- CAS No.: 946417-21-6
- 화학식: C24H23NO9P2S
- 분자량:563.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 946417-21-6
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분자량 563.45
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화학식 C24H23NO9P2S
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SMILES
O=P(O)(C(CC1=CC=CC(C2=CC=CC(NS(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)=C2)=C1)(P(O)(O)=O)O)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Guo RT, et al. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. [Content Brief]
[2]. Chong D, et al. Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo. J Genet Genomics. 2021 Apr 20;48(4):300-311. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BPH-675 Related Classifications
HY-136829 Related Classifications
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