Brostallicin
Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 203258-38-2
- 화학식: C30H36BrClN12O5
- 분자량:760.04
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
0.64 nM
Compound: 17 (brostallicin)
|
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)
|
[PMID: 15115402] |
| L1210 | IC50 |
1.8 nM
Compound: 9
|
In vitro cytotoxicity against L1210 murine leukemia cells after 48 hr of continuous exposure
In vitro cytotoxicity against L1210 murine leukemia cells after 48 hr of continuous exposure
|
[PMID: 12031321] |
| L1210 | IC50 |
1.85 nM
Compound: 17 (brostallicin)
|
In vitro test for cytotoxicity against L1210 murine leukemia cells
In vitro test for cytotoxicity against L1210 murine leukemia cells
|
[PMID: 15115402] |
| L1210 | IC50 |
2.13 nM
Compound: 17 (brostallicin)
|
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells
|
[PMID: 15115402] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 203258-38-2
-
분자량 760.04
-
화학식 C30H36BrClN12O5
-
SMILES
O=C(C(Br)=C)NC1=CN(C)C(C(NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCNC(N)=N)=O)=C4)=O)=C3)=O)=C2)=O)=C1.Cl
-
Synonyms
PNU-166196
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Brostallicin Related Classifications
HY-16117A Related Classifications
Powered by Bioz