C10 Bisphosphonate
Based on 1 Customer Validation
C10 Bisphosphonate is an acid sphingomyelinase (aSMase) inhibitor with an IC50 of 0.02 μM in rats. C10 Bisphosphonate inhibits Dexamethasone (HY-14648)-induced cell apoptosis (apoptosis) and alleviates platelet-activating factor (PAF)-induced pulmonary edema. C10 Bisphosphonate can be used for the research of pulmonary edema.
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- Purity : 98.87%
- CAS No.: 15049-93-1
- 화학식: C10H25NO6P2
- 분자량:317.26
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Biological Activity
제품 설명
In Vitro
C10 Bisphosphonate (compound 7c) potently inhibits aSMase derived from crude rat brain extracts, with an IC50 of 0.02 μM[1].
C10 Bisphosphonate (0.1 μM; 7 h) effectively inhibits Dexamethasone (HY-14648)-induced apoptosis of HepG2 hepatocytes[1].
C10 Bisphosphonate (0.1-1 μM) reduces PAF-induced pulmonary edema in isolated perfused rats in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 liver cells
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Concentration:0.1 μM
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Incubation Time:7 h
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Result:Efficiently inhibited dexamethasone-induced apoptosis, as measured by reduced absorbance in a DNA-fragmentation ELISA.
Chemical Information
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CAS No. 15049-93-1
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Appearance Solid
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분자량 317.26
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화학식 C10H25NO6P2
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Color White to off-white
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SMILES
O=P(O)(C(CCCCCCCCC)(P(O)(O)=O)N)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
C10 Bisphosphonate Related Classifications
HY-48917 Related Classifications
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