CAIF
CAIF is an irreversible, selective allosteric covalent inhibitor of ucosyltransferase 8 (FUT8) with an IC50 of 5.7 μM. CAIF inhibits core fucosylation modification in cancer cells, and suppresses the invasion and migration of cancer cells. CAIF is applicable for cancer research.
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- 화학식: C27H46BrN3O4
- 분자량:556.58
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
CAIF (0-500 μM; 72 h) exhibits extremely low cytotoxicity in HeLa, A375, GAK and HEK293T cells, with no toxicity detected at the concentration of 500 μM in HeLa and GAK cells[1].
CAIF (0-300 μM; 72 h) significantly inhibits core fucosylation in HeLa, A375 and GAK cells, with an EC50 of 38.4 μM in GAK cells[1].
CAIF (1-100 μM; 72 h) inhibits the invasion of HeLa cells in vitro, and its efficacy is superior to that of 2FF at the tested concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa
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Concentration:1, 10, 50, 100 μM
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Incubation Time:48 h (pretreatment); 24 h (invasion assay incubation at 37 °C)
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Result:Outperformed 2FF in suppressing HeLa cell migration and invasion in the in vitro invasion assay.
Chemical Information
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분자량 556.58
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화학식 C27H46BrN3O4
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SMILES
C[N+]1=C(C)N(C=C1)CCCCCCCCCCCCCCCCCC(ON2C(CCC2=O)=O)=O.[Br-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAIF Related Classifications
HY-181989 Related Classifications
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