Caloxin 1C2
Based on 1 Customer Validation
Caloxin 1C2 is a specific PMCA (plasma-membrane Ca2+-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The Ki values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca2+ transfer. Caloxin 1C2 affects coronary contractility.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.47%
- 화학식: C80H134N26O24
- 분자량:1844.08
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
Ki: 2.3±0.3 μM (PMCA4), 21±6 μM (PMCA1)[2]
Chemical Information
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Appearance Solid
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분자량 1844.08
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화학식 C80H134N26O24
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Color White to off-white
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Sequence
Thr-Ala-Trp-Ser-Glu-Val-Leu-Asp-Leu-Leu-Arg-Arg-Gly-Gly-Gly-Ser-Lys-NH2
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Sequence Shortening
TAWSEVLDLLRRGGGSK-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 100 mg/mL (54.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sillanpää JK, et al. Calcium transfer across the outer mantle epithelium in the Pacific oyster, Crassostrea gigas. Proc Biol Sci. 2018 Nov 14;285(1891):20181676. [Content Brief]
[2]. Pande J, et al. Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca(2+)-pump isoform 4, on coronary artery. J Cell Mol Med. 2008 Jun;12(3):1049-60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5423 mL | 2.7114 mL | 5.4228 mL | 13.5569 mL |
| 5 mM | 0.1085 mL | 0.5423 mL | 1.0846 mL | 2.7114 mL | |
| 10 mM | 0.0542 mL | 0.2711 mL | 0.5423 mL | 1.3557 mL | |
| 15 mM | 0.0362 mL | 0.1808 mL | 0.3615 mL | 0.9038 mL | |
| 20 mM | 0.0271 mL | 0.1356 mL | 0.2711 mL | 0.6778 mL | |
| 25 mM | 0.0217 mL | 0.1085 mL | 0.2169 mL | 0.5423 mL | |
| 30 mM | 0.0181 mL | 0.0904 mL | 0.1808 mL | 0.4519 mL | |
| 40 mM | 0.0136 mL | 0.0678 mL | 0.1356 mL | 0.3389 mL | |
| 50 mM | 0.0108 mL | 0.0542 mL | 0.1085 mL | 0.2711 mL |
Caloxin 1C2 Related Classifications
HY-P10655 Related Classifications
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