Carbodine
Carbodine (Carbocyclic cytidine) is a broad-spectrum antiviral agent active against DNA viruses, (+)RNA viruses, (-)RNA viruses, paramyxo, rhabdo and (+/-)RNA viruses, targets CTP synthetase that converts UTP to CTP. Carbodine (Carbocyclic cytidine) possesses significant antiviral activity against influenza virus types A0/PR-8/34 and A2/Aichi/2/68 in vitro.
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- CAS No.: 71184-20-8
- 화학식: C10H15N3O4
- 분자량:241.24
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | EC50 |
0.7 μM
Compound: (+/-)-Carbodine
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Antiviral activity against Influenza A virus Hong Kong/213/2003/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days
Antiviral activity against Influenza A virus Hong Kong/213/2003/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days
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[PMID: 20231094] |
| MDCK | IC50 |
>414 μM
Compound: (+/-)-Carbodine
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Cytotoxicity against MDCK cells after 3 days by neutral red dye uptake assay
Cytotoxicity against MDCK cells after 3 days by neutral red dye uptake assay
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[PMID: 20231094] |
Chemical Information
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CAS No. 71184-20-8
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분자량 241.24
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화학식 C10H15N3O4
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SMILES
O=C1N=C(N)C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. De Clercq E, et al. Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine. Biochem Pharmacol. 1990 Jan 15;39(2):319-25. [Content Brief]
[2]. Shannon WM, et al. Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses. Antimicrob Agents Chemother. 1981 Dec;20(6):769-76. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carbodine Related Classifications
HY-128718 Related Classifications
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