(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu)

  • Bioorg Med Chem Lett. 2010 Apr 15;20(8):2601-4. doi: 10.1016/j.bmcl.2010.02.074.
Jagadeeshwar R Rao  1 ,  Ashok K Jha ,  Ravindra K Rawal ,  Ashoke Sharon ,  Craig W Day ,  Dale L Barnard ,  Donald F Smee ,  Chung K Chu
Affiliations
  • 1. The University of Georgia College of Pharmacy, Athens, GA 30602, USA.
PMID: 20231094 DOI: 10.1016/j.bmcl.2010.02.074
Abstract

Enantiomerically pure cyclopentyl cytosine [(-)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine, (+/-)-carbodine and ribavirin. (-)-Carbodine 1 exhibited potent Antiviral activity against various strains of influenza A and B viruses.