179556-82-2
179556-82-2
Chemical Structure
U-101958
- CAS No.: 179556-82-2
- Formula:C21H29N3O
- Molecular Weight:339.47
InChIKey: WFLHEXUTTRRXFJ-UHFFFAOYSA-N
SMILES: CC(C)OC1=CC=CN=C1N(C2CCN(CC2)CC3=CC=CC=C3)C
Biological Activity: U-101958 is a selective dopamine D4R antagonist. U-101958 binds to human D4 with a Ki of 1.4 nM and a pKi of 8.9. U-101958 inhibits Quinpirole (HY-B1752)-induced mitogenic effects. U-101958 can be used for research on schizophrenia[1][2][3][4][5][6].
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U-101958 | U-101958 is a selective dopamine D4R antagonist. U-101958 binds to human D4 with a Ki of 1.4 nM and a pKi of 8.9. U-101958 inhibits Quinpirole (HY-B1752)-induced mitogenic effects. U-101958 can be used for research on schizophrenia. | |||||||||||||||||||||
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References
- [1]. Onn SP, et al. Dopamine D1 and D4 receptor subtypes differentially modulate recurrent excitatory synapses in prefrontal cortical pyramidal neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2006 Feb;31(2):318-38. [Content Brief]
- [2]. Schlachter SK, et al. Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor. European journal of pharmacology. 1997 Mar 19;322(2-3):283-6.
- [3]. Florán B, et al. Activation of dopamine D4 receptors modulates [3H] GABA release in slices of the rat thalamic reticular nucleus. Neuropharmacology. 2004 Mar 1;46(4):497-503.
- [4]. Gazi L, et al. The agonist activities of the putative antipsychotic agents, L‐745,870 and U‐101958 in HEK293 cells expressing the human dopamine D4. 4 receptor. British journal of pharmacology. 1998 Jul;124(5):889-96. [Content Brief]
- [5]. Ma L, et al. Activation of glutathione peroxidase and inhibition of p53-related apoptosis by apomorphine. Journal of Alzheimer's disease : JAD. 2011;27(1):225-37. [Content Brief]
- [6]. Gazi L, et al. Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L‐745,870 and U‐101958 at human recombinant D4. 4 receptors expressed in CHO cells. British journal of pharmacology. 1999 Oct;128(3):613-20. [Content Brief]
