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Cat. No.: HY-182449

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CCT365386

CCT365386 is a BCL6 inhibitor. CCT365386 serves as an optimized lead compound for cell-active BCL6 degraders (including CCT369260 (HY-129188)). CCT365386 can be used in the research of B-cell lymphoma.

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CAS No.: 2647503-59-9
화학식: C₁₅H₁₂ClN₅O
분자량:313.74

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CCT365386 Chemical Structure

CAS No.: 2647503-59-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

All Bcl-2 Family Isoforms :

In Vitro

CCT365386 (Compound 1) inhibits the interaction between the BCL6 BTB domain and corepressor peptides in TR-FRET biochemical assays, with an IC₅₀ of 3.27 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2647503-59-9
분자량 313.74
화학식 C₁₅H₁₂ClN₅O
SMILES

N#CC1=C(NC2=CC=C3C(N(C)C(N3C)=O)=C2)C=CN=C1Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lloyd MG, et al. Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket. J Med Chem. 2021;64(23):17079-17097. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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CCT365386

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CCT365386 Related Classifications

HY-182449 Related Classifications