country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187718

Copy Link Print Information

CGC-11150

CGC-11150 is a decamine-based polyamine analog that acts as a voltage-dependent pore blocker of Kir channels. CGC-11150 produces voltage-dependent pore block similar to that of Spermine (HY-B1777) in recombinant Kir6.2^{[N160D, L164C, C166S, Δ36]} + SUR1 channels, but with faster on and off rates. CGC-11150 inhibits the development of and induces regression of laser-induced choroidal neovascularization (CNV). CGC-11150 is used in studies related to choroidal neovascularization.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 304911-08-8
화학식: C₄₀H₉₀N₁₀·10HCl
분자량:1075.82

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CGC-11150 Chemical Structure

CAS No.: 304911-08-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

CGC-11150 (1 μM) induces voltage-dependent inward rectification of Kir6.2-rec channels expressed in COSm6 cells, with blocking characteristics similar to spermine but slightly reduced potency and faster on/off rates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Local Vascular Regulation

CGC-11150 (10-20 mg/kg; i.p.; 2 to 3 times per week; for 14 days) causes a slight reduction in CNV area, but exhibits poor tolerability at high doses^[2].
CGC-11150 (20 μg; intravitreal injection; administered on day 0 and day 7 post-injury) reduces the CNV area by approximately 40% in a mouse model of laser-induced choroidal neovascularization^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (female, 4 to 5 weeks old, laser-induced rupture of Bruch’s membrane)^[2]
Dosage:

10 mg/kg; 20 mg/kg (i.p.); 20 μg (intravitreous)
Administration:

i.p.; twice a week; 14 days; i.p.; three times a week; 14 days; intravitreous; on days 0 and 7 after injury
Result:

Caused a small reduction in CNV lesion area.
Was not well tolerated (several mice died), but surviving mice showed a small reduction in CNV lesion area comparable to the 10 mg/kg dose.
Resulted in an approximately 40% reduction in CNV lesion area compared to vehicle-treated or untreated eyes.
Caused retinal damage.

Chemical Information

CAS No. 304911-08-8
분자량 1075.82
화학식 C₄₀H₉₀N₁₀·10HCl
SMILES

CCNCCCCNCCCCNCCCCNCCCCNC/C=C\CNCCCCNCCCCNCCCCNCCCCNCC.Cl.[10]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Loussouarn G, et al. Molecular basis of inward rectification: structural features of the blocker defined by extended polyamine analogs. Molecular pharmacology. 2005 Aug;68(2):298-304.

[2]. Lima e Silva R, et al. Suppression and regression of choroidal neovascularization by polyamine analogues. Investigative ophthalmology & visual science. 2005 Sep;46(9):3323-30.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기