Cilazaprilat
Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50=0.7 nM for the rat enzyme) and an active metabolite of Cilazapril (HY-A0043). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 μM.3 Intra-arterial administration of cilazaprilat (3 μg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.
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- CAS No.: 90139-06-3
- 화학식: C20H27N3O5
- 분자량:389.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Chemical Information
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CAS No. 90139-06-3
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분자량 389.45
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화학식 C20H27N3O5
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SMILES
O=C([C@@H]1CCCN2N1C([C@@H](N[C@H](C(O)=O)CCC3=CC=CC=C3)CCC2)=O)O
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Synonyms
Ro 31-3113
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cilazaprilat Related Classifications
HY-A0113 Related Classifications
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