CRL-42872
CRL-42872 is an orally active, highly bioavailable Gp IIb/IIIa platelet receptor inhibitor. CRL-42872 inhibits the binding of fibrinogen to the Gp IIb/IIIa receptor, thereby suppressing collagen-induced platelet aggregation. CRL-42872 is widely used in thrombosis-related studies.
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- CAS No.: 256385-24-7
- 화학식: C22H27ClN6O6S
- 분자량:539.00
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
CRL-42872 (1.5×10-8 M - 7×10-5 M; 3 minutes) potently inhibits collagen-induced aggregation of guinea pig platelets with an IC50 of 9.4×10-8 M[1].
CRL-42872 (10-8 M - 5×10-5 M; 3 minutes) inhibits collagen-induced aggregation of human platelets with an IC50 of 1.2×10-7 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dunkin-Hartley (male, ~330 g)[1]
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Dosage:10 mg/kg
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Administration:p.o.; single dose
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Result:Inhibited collagen-induced platelet aggregation by 68% at 1 hour post-administration.
Inhibited collagen-induced platelet aggregation by 64% at 2 hours post-administration.
Chemical Information
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CAS No. 256385-24-7
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분자량 539.00
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화학식 C22H27ClN6O6S
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SMILES
O=C1CN(C2=CC=C(C=C2)C(N)=N)CCN1CC(NC[C@@H](C(O)=O)NS(=O)(C3=CC=CC=C3)=O)=O.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CRL-42872 Related Classifications
HY-119238 Related Classifications
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