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Cat. No.: HY-119238

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CRL-42872

CRL-42872 is an orally active, highly bioavailable Gp IIb/IIIa platelet receptor inhibitor. CRL-42872 inhibits the binding of fibrinogen to the Gp IIb/IIIa receptor, thereby suppressing collagen-induced platelet aggregation. CRL-42872 is widely used in thrombosis-related studies.

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CAS No.: 256385-24-7
화학식: C₂₂H₂₇ClN₆O₆S
분자량:539.00

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

CRL-42872 Chemical Structure

CAS No.: 256385-24-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

CRL-42872 (1.5×10^-8 M - 7×10^-5 M; 3 minutes) potently inhibits collagen-induced aggregation of guinea pig platelets with an IC₅₀ of 9.4×10^-8 M^[1].
CRL-42872 (10^-8 M - 5×10^-5 M; 3 minutes) inhibits collagen-induced aggregation of human platelets with an IC₅₀ of 1.2×10^-7 M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CRL-42872 (10 mg/kg; p.o.; single dose) achieves inhibition of collagen-induced guinea pig platelet aggregation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Dunkin-Hartley (male, ~330 g)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; single dose
Result:

Inhibited collagen-induced platelet aggregation by 68% at 1 hour post-administration.
Inhibited collagen-induced platelet aggregation by 64% at 2 hours post-administration.

Chemical Information

CAS No. 256385-24-7
분자량 539.00
화학식 C₂₂H₂₇ClN₆O₆S
SMILES

O=C1CN(C2=CC=C(C=C2)C(N)=N)CCN1CC(NC[C@@H](C(O)=O)NS(=O)(C3=CC=CC=C3)=O)=O.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yue C, et al. Substituted piperazinones and their therapeutic uses: U.S. Patent 6,335,337[P]. 2002-1-1.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

CRL-42872