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Cat. No.: HY-P11926

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Cys-CPP44

Name: Cys-CPP44
Brand: MedChemExpress
SKU: HY-P11926
Availability: PreOrder

Cys-CPP44 is a cell-penetrating peptide with a Cys introduced at the N-terminus, which can specifically penetrate hepatocellular carcinoma cells. Modification with Cys-CPP44 promotes the specific penetration of arsenic trioxide-loaded liposomes into hepatocellular carcinoma cells and enhances the cellular uptake of liposomes by these cells. Cys-CPP44 can be used for the research of hepatocellular carcinoma.

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화학식: C₉₄H₁₄₇N₂₉O₂₁S₃
분자량:2115.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

Cys-CPP44 Chemical Structure

사이즈

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

OthersAnti-cancer

Others

Cys-CPP44 forms DSPE-PEG-MAL-CPP44 conjugate whose successful synthesis is verified by MALDI-TOF-MS at m/z = 5042.349[1].
Cys-CPP44 significantly elevates the uptake efficiency of modified liposomes (CPP44-Lp) in HepG2 cells compared with unmodified liposomes^[1].

Anti-cancer

Cys-CPP44-modified ATO liposomes (CPP44-ATO-Lp) significantly reduce the viability of HepG2 cells compared with free ATO and unmodified ATO-Lp; after incubation with 0.05 μM ATO for 24 h, the total apoptosis rate of HepG2 cells reaches 25.48%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Cys-CPP44 combined with anti-GPC3 antibody forms dual-ligand liposomes (0.1 mg/kg; intravenous injection; once every two days for 18 days), which deliver arsenic trioxide to subcutaneous hepatocellular carcinoma tumours in BALB/c nude mice, achieve a tumour inhibition rate of 63.43% and exhibit low systemic toxicity^[1].
Cys-CPP44 paired with anti-GPC3 antibody constructs dual-ligand liposomes (1 mg/kg; intravenous injection; single administration), which display enhanced tumour-targeted accumulation and prolonged retention in orthotopic hepatocellular carcinoma tumours of BALB/c nu/nu mice, with 1.43-fold higher tumour fluorescence intensity at 24 h post-administration relative to unmodified liposomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Liver Cancer Modeling

Chemical Information

분자량 2115.55
화학식 C₉₄H₁₄₇N₂₉O₂₁S₃
Sequence

CKRPTMRFRYTWNPMK
Sequence Shortening

Cys-Lys-Arg-Pro-Thr-Met-Arg-Phe-Arg-Tyr-Thr-Trp-Asn-Pro-Met-Lys
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lin C, et al. Anti-GPC3 antibody and cell-penetrating peptide CPP44 dual-ligand modified liposomes for targeted delivery of arsenic trioxide in the treatment of hepatocellular carcinoma. Journal of drug targeting. 2025 Jul;33(6):1004-1013.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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