DC_M5_2
DC_M5_2 is a WD40 repeat domain protein 5 (WDR5) inhibitor with an IC50 of 9.63 μM and a KD of 13.8 μM. DC_M5_2 binds to the WDR5 pocket that interacts with the MLL1 peptide, blocking the WDR5-MLL1 protein-protein interaction. DC_M5_2 can be used in leukemia-related research.
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- CAS No.: 713099-37-7
- 화학식: C22H22BrNO5
- 분자량:460.32
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
DC_M5_2 inhibits the WDR5-MLL1 interaction with an IC50 of 9.63 µM by binding to WDR5 through hydrophobic contacts and hydrogen bonds[1].
DC_M5_2 binds directly to purified WDR5 protein in vitro with a Kd of 13.8 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 713099-37-7
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분자량 460.32
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화학식 C22H22BrNO5
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SMILES
O=C(COC1=CC=C(C=C1C2C3=C(N(C)C4=C2C(CCC4)=O)CCCC3=O)Br)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Gurung R, et al. Recent Progress in Modulation of WD40-Repeat Domain 5 Protein (WDR5): Inhibitors and Degraders. Cancers (Basel). 2023;15(15):3910. Published 2023 Aug 1. [Content Brief]
[2]. Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019;29(4):638-645. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DC_M5_2 Related Classifications
HY-183959 Related Classifications
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