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Cat. No.: HY-D3207

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DHUCu-1

DHUCu-1 is a lysosome-targeted NIR divalent copper ion probe with high water solubility. DHUCu-1 serves as a tool for investigating the physiological functions of Cu²⁺ and related diseases, such as Menke syndrome, Wilson's disease, and Alzheimer's disease.

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CAS No.: 3037311-41-1
화학식: C₁₇H₂₁N₅OS
분자량:343.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DHUCu-1 Chemical Structure

CAS No.: 3037311-41-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

DHUCu-1 (5 μM) exhibits concentration-dependent fluorescence and absorbance changes with Cu²⁺ (0-20 μM) in PBS solution containing 1% alcohol cosolvent, enabling visual and spectroscopic detection of Cu²⁺^[1].
DHUCu-1 (5 μM) enables highly sensitive detection of Cu²⁺ in aqueous solution, with a limit of detection of 19.1 nM, and shows a linear fluorescence response to Cu²⁺ in the concentration range of 0 to 3.0 μM^[1].
DHUCu-1 (50 μM; 24 h) exhibits low toxicity and good biocompatibility toward HeLa cells, with an observed cell viability of over 80%^[1].
DHUCu-1 (10 μM; 1 h) acts as an activatable fluorescent probe for exogenous Cu²⁺ (20-50 μM; 1 h) in HeLa cells, generating a detectable near-infrared fluorescent signal^[1].
DHUCu-1 (10 μM; 1 h) accumulates in the lysosomes of HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa cells
Concentration:

50 μM
Incubation Time:

24 h
Result:

Maintained HeLa cell survival rate above 80% after incubation.

Related Protocols :

Chemical Information

CAS No. 3037311-41-1
분자량 343.45
화학식 C₁₇H₂₁N₅OS
SMILES

CN(C1=CC=C2C(SC3=C(N2C(NN)=O)C=CC(N(C)C)=C3)=C1)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yin Chen, et al. A lysosome-targeted near-infrared fluorescent probe for cell imaging
of Cu2+. Dyes and Pigments 204 (2022) 110472.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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