Dihydrokainic acid
Based on 2 publication(s) in Google Scholar
Dihydrokainic acid is a glutamate transporters (especially GLT1) inhibitor. Dihydrokainic acid targets GLT1 with high affinity, effectively inhibiting its transport function. Dihydrokainic acid exerts its effect by inhibiting the uptake of glutamate, leading to an increase in extracellular glutamate concentration, thereby affecting neuronal excitability and neurotransmission. Dihydrokainic acid is mainly applied in the field of neuroscience for research on glutamate-related neural functions, epilepsy, learning, and memory.
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- Purity: 99.0%
- CAS No.: 52497-36-6
- 화학식: C10H17NO4
- 분자량:215.25
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dihydrokainic acid
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Biological Activity
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EAAT2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>3000 μM
Compound: DHK, dihydrokainic acid
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Inhibition of glutamate-induced depolarization in human EAAT3 expressed in HEK293 cells by FMP assay
Inhibition of glutamate-induced depolarization in human EAAT3 expressed in HEK293 cells by FMP assay
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[PMID: 18578477] |
| HEK293 | IC50 |
89 μM
Compound: DHK, dihydrokainic acid
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Inhibition of glutamate-induced depolarization in human EAAT2 expressed in HEK293 cells by FMP assay
Inhibition of glutamate-induced depolarization in human EAAT2 expressed in HEK293 cells by FMP assay
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[PMID: 18578477] |
| HEK293 | IC50 |
>3000 μM
Compound: DHK, dihydrokainic acid
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Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay
Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay
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[PMID: 18578477] |
Dihydrokainic acid (5 mM; treating cerebellar slices for 15 min) inhibits the uptake of D-[3H]aspartate by cerebellar slices in a concentration-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming strain male mice (male, 35-40 g, not specified age) + novel object recognition (NOR) memory model[4]
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Dosage:6.25, 12.5, 25 nmol (0.01 M PBS, pH 7.4)
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Administration:Unilaterally injected into the cerebral ventricle, once at 0.5 h before sampling or 0.5 h before testing
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Result:Impaired short-term and long-term NOR memory performance, affecting memory acquisition, consolidation, and retrieval.
Chemical Information
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CAS No. 52497-36-6
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Appearance Solid
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분자량 215.25
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화학식 C10H17NO4
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Color White to off-white
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SMILES
O=C(O)C[C@@H]1[C@@H](C(O)=O)NC[C@@H]1C(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Adv Res
IFITM3 knockout alleviates neuronal parthanatos by restoring astrocytic glutamate uptake in intracerebral hemorrhage mice. [Abstract]2026 May 16:S2090-1232(26)00437-6. PMID: 42144055 -
Cell Chem Biol
Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma. [Abstract]2025 Jun 19;32(6):885-898.e11. PMID: 40466640
용액&용해도
H2O : 5 mg/mL (23.23 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Bouazzaoui M, et al. Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices. Neurochem Res. 1996 Dec;21(12):1527-33. [Content Brief]
[3]. Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27(4):375-81. [Content Brief]
[4]. Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.6458 mL | 23.2289 mL | 46.4578 mL | 116.1446 mL |
| 5 mM | 0.9292 mL | 4.6458 mL | 9.2916 mL | 23.2289 mL | |
| 10 mM | 0.4646 mL | 2.3229 mL | 4.6458 mL | 11.6145 mL | |
| 15 mM | 0.3097 mL | 1.5486 mL | 3.0972 mL | 7.7430 mL | |
| 20 mM | 0.2323 mL | 1.1614 mL | 2.3229 mL | 5.8072 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dihydrokainic acid Related Classifications
HY-100784 Related Classifications
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