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Cat. No.: HY-146455

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DPP-4-IN-3

DPP-4-IN-3 (Compound 5a) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 0.75 nM. DPP-4-IN-3 shows excellent antioxidant and insulinotropic activity.

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CAS No.: 2402735-14-0
화학식: C₁₉H₂₂N₆O₂
분자량:366.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DPP-4-IN-3 Chemical Structure

CAS No.: 2402735-14-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

DPP-4-IN-3 (Compound 5a) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 0.75 nM. DPP-4-IN-3 shows excellent antioxidant and insulinotropic activity^[1].

IC₅₀ & Target

DPP-4

All Dipeptidyl Peptidase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
INS1(832/13)	IC₅₀	0.0028 μM Compound: 5a	Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase in insulin release in presence of 3 mM glucose measured after 2 hrs by radioimmunoassay Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase in insulin release in presence of 3 mM glucose measured after 2 hrs by radioimmunoassay	[PMID: 31812034]

Chemical Information

CAS No. 2402735-14-0
분자량 366.42
화학식 C₁₉H₂₂N₆O₂
SMILES

CCOC(N1CCN(CC1)C2=NN3C(C=C2)=NN=C3C4=CC=CC(C)=C4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bindu B, et al. Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities. Eur J Med Chem. 2020 Feb 1;187:111912. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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DPP-4-IN-3

All Dipeptidyl Peptidase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DPP-4-IN-3 Related Classifications

HY-146455 Related Classifications