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Cat. No.: HY-131551

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Drometrizole

Name: Drometrizole
Brand: MedChemExpress
SKU: HY-131551
Price: 60.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

Drometrizole is an orally active UV absorber and can be used in cosmetic research. Drometrizole has low acute toxicity, no teratogenicity and carcinogenicity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 99.81%
CAS No.: 2440-22-4
화학식: C₁₃H₁₁N₃O
분자량:225.25

보관:

RT, stored under nitrogen.

In solvent -80°C, 1 year , -20°C, 6 months

Drometrizole Chemical Structure

CAS No.: 2440-22-4

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-131551R
Drometrizole (Standard)

Standard of Drometrizole

Biological Activity

제품 설명

Drometrizole is an orally active UV absorber and can be used in cosmetic research. Drometrizole has low acute toxicity, no teratogenicity and carcinogenicity^[1]^[2].

In Vivo

Drometrizole exhibits oral bioavailability of 94.3% (30 mg/kg) and 2.13% (300 mg/kg) in male rats after a single oral administration^[1].
Pharmacokinetic Analysis in Male Rats^[1]

Route	Dose (mg/kg)	T_max (h)	C_max (ng/mL)	Half-life (h)	AUC (h·ng/mL)
i.v.	2.25	/	4510	84.8	10500
i.g.	30	0.0196	138	1120	132000
i.g.	300	0.266	358	103	29800

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2440-22-4
Appearance Solid
분자량 225.25
화학식 C₁₃H₁₁N₃O
Color White to off-white
SMILES

OC1=CC=C(C)C=C1N2N=C3C(C=CC=C3)=N2
선적

Room temperature in continental US; may vary elsewhere.

보관

RT, stored under nitrogen

In solvent	-80°C	1 year
	-20°C	6 months

용액&용해도

In Vitro:

DMSO : 50 mg/mL (221.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4395 mL

22.1976 mL

44.3951 mL

5 mM

0.8879 mL

4.4395 mL

8.8790 mL

10 mM

0.4440 mL

2.2198 mL

4.4395 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.10 mM); Suspended solution

This protocol yields a suspended solution of ≥ 2.5 mg/mL (saturation unknown). Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Waidyanatha S, et al. Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats. Xenobiotica. 2021 Jul;51(7):831-841. [Content Brief]

[2]. Lee JK, et al. Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber. Toxicol Res. 2019;35(2):119-129. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.4395 mL	22.1976 mL	44.3951 mL	110.9878 mL
	5 mM	0.8879 mL	4.4395 mL	8.8790 mL	22.1976 mL
	10 mM	0.4440 mL	2.2198 mL	4.4395 mL	11.0988 mL
	15 mM	0.2960 mL	1.4798 mL	2.9597 mL	7.3992 mL
	20 mM	0.2220 mL	1.1099 mL	2.2198 mL	5.5494 mL
	25 mM	0.1776 mL	0.8879 mL	1.7758 mL	4.4395 mL
	30 mM	0.1480 mL	0.7399 mL	1.4798 mL	3.6996 mL
	40 mM	0.1110 mL	0.5549 mL	1.1099 mL	2.7747 mL
	50 mM	0.0888 mL	0.4440 mL	0.8879 mL	2.2198 mL
	60 mM	0.0740 mL	0.3700 mL	0.7399 mL	1.8498 mL
	80 mM	0.0555 mL	0.2775 mL	0.5549 mL	1.3873 mL
	100 mM	0.0444 mL	0.2220 mL	0.4440 mL	1.1099 mL

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Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vivo
Chemical Information
용액&용해도
- In Vitro
- In Vivo
순도&문서
References

상품명:
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상품명:
CAS No.:
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Purity:
수량:

Drometrizole

Biological Activity

제품 설명

In Vivo

Chemical Information

용액&용해도

In Vitro:

In Vivo:

In Vivo Dissolution Calculator

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Drometrizole Related Classifications

HY-131551 Related Classifications

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