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Cat. No.: HY-123878

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DS79182026

DS79182026 is an inhibitor of hepcidin production. DS79182026 exhibits hepcidin lowering ability in IL-6-induced acute inflammatory mouse model.

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CAS No.: 2113642-80-9
화학식: C₁₈H₁₅N₅O₃
분자량:349.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DS79182026 Chemical Structure

CAS No.: 2113642-80-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

DS79182026 is an inhibitor of hepcidin production. DS79182026 exhibits hepcidin lowering ability in IL-6-induced acute inflammatory mouse model^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	0.039 μM Compound: 38	Inhibition of human recombinant BMP6-stimulated hepcidin mRNA expression in human HepG2 cells after 6 hrs by qRT-PCR analysis Inhibition of human recombinant BMP6-stimulated hepcidin mRNA expression in human HepG2 cells after 6 hrs by qRT-PCR analysis	[PMID: 28705644]

Chemical Information

CAS No. 2113642-80-9
분자량 349.34
화학식 C₁₈H₁₅N₅O₃
SMILES

O=C(OC)NC1=NOC2=CC(C3=C(C)NN=C3C4=NC=CC=C4)=CC=C12
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fukuda, T., et al., (2017). Discovery of DS79182026: A potent orally active hepcidin production inhibitor. Bioorganic & medicinal chemistry letters, 27(16), 3716-3722. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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