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Cat. No.: HY-105193

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E 3040

E 3040 is an orally active dual inhibitor of 5-lipoxygenase and thromboxane synthase. E 3040 exhibits anti-inflammatory effect.

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CAS No.: 145096-30-6
화학식: C₁₆H₁₇N₃OS
분자량:299.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

E 3040 Chemical Structure

CAS No.: 145096-30-6

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

E 3040 is an orally active dual inhibitor of 5-lipoxygenase and thromboxane synthase. E 3040 exhibits anti-inflammatory effect^[1].

IC₅₀ & Target^[1]

5-Lipoxygenase

All Lipoxygenase Isoforms :

All Prostaglandin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RBL-1	IC₅₀	0.23 μM Compound: 26a	Tested for inhibitory activity against 5-lipoxygenase in microsome of RBL-1 cells Tested for inhibitory activity against 5-lipoxygenase in microsome of RBL-1 cells	[PMID: 7932529]

In Vivo

E 3040 (30-100 mg/kg, p.o.) shows anti-inflammation effect in LPS (HY-D1056)-treated rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS (HY-D1056)-treated rats^[1]
Dosage:

30 and 100 mg/kg
Administration:

Orally administration
Result:

Inhibited the increase in vascular permeability.
Inhibited the production of leukotriene B(4) and thromboxane B(2).
Increased the production of prostaglandin E(2).

Chemical Information

CAS No. 145096-30-6
분자량 299.39
화학식 C₁₆H₁₇N₃OS
SMILES

OC1=C(C)C(CC2=CC=CN=C2)=C3N=C(NC)SC3=C1C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Oketani K, et al. Effect of E3040, an inhibitor of 5-lipoxygenase and thromboxane synthase, on rat bowel damage induced by lipopolysaccharide. Eur J Pharmacol. 2001 Sep 14;427(2):159-66. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
CAS No.:
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E 3040

All Lipoxygenase Isoforms

All Prostaglandin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

E 3040 Related Classifications

HY-105193 Related Classifications