E197
Based on 1 Customer Validation
E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC50=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC50 of 36 μM. E197 prevents the bone loss in mouse ovariectomized models.
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- Purity: 99.91%
- CAS No.: 2378515-04-7
- 화학식: C19H21ClN2O3S
- 분자량:392.90
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Osteoclast | IC50 |
3.44 μM
Compound: E197
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Inhibition of resorption activity of mouse peripheral blood cell-derived osteoclasts incubated for 48 hrs by Kossa-staining based assay
Inhibition of resorption activity of mouse peripheral blood cell-derived osteoclasts incubated for 48 hrs by Kossa-staining based assay
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[PMID: 33175535] |
Chemical Information
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CAS No. 2378515-04-7
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Appearance Solid
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분자량 392.90
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화학식 C19H21ClN2O3S
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Color White to off-white
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SMILES
O=S1([C@]2(CN(CC2)CC3=CC=C(C=C3)Cl)[C@H](CN1C4=CC=CC=C4)O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E197 Related Classifications
HY-164587 Related Classifications
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