Eco-DEHCH
Eco-DEHCH is a phthalate-free alternative plasticizer that safely and effectively softens plastics such as flexible PVC. Eco-DEHCH shows low binding affinity for various endocrine receptors, including estrogen, androgen, glucocorticoid, thyroid receptor α and thyroid receptor β. Eco-DEHCH causes dose-dependent accumulation of α2u-globulin in the kidneys of male Han Wistar rats, but has overall general safety.
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- CAS No.: 84731-70-4
- 화학식: C24H44O4
- 분자량:396.60
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Eco-DEHCH shows low binding affinity to human ERα, AR, GR, TRα, and TRβ, with binding scores of -6.9, -5.3, -7, -6.5, and -7.7 kcal/mol respectively, all weaker than the respective positive controls[1].
Eco-DEHCH exhibits no agonistic or antagonistic effects on human ERα in hERα-HeLa-9903 cells or on human AR in 22Rv1/MMTV_GR-KO cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Eco-DEHCH (1,600-16,000 ppm; p.o.; daily; 52 weeks) has generally safe chronic 52-week dietary exposure in Han Wistar rats, with the only exposure-related effect being male-specific α2u-globulin accumulation (not relevant to humans), and the no-observed-adverse-effect level (NOAEL) is the highest tested dose of 16,000 ppm (estimated 912.8 mg/kg/day for males, 1,208.2 mg/kg/day for females)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type (adult breeders aged 7-13 months; embryos/larvae from 2 hours post-fertilization to 120 hours post-fertilization)[1]
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Dosage:0.01 μM; 0.1 μM; 1 μM; 10 μM
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Administration:static immersion; 2 hpf to 120 hpf
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Result:Showed no significant changes in average locomotor distance under light or dark conditions.
Did not alter the expression of nine endocrine-related genes across the hypothalamic-pituitary-adrenal, hypothalamic-pituitary-gonadal, and hypothalamic-pituitary-thyroid axes at any tested concentration.
Did not significantly alter endogenous concentrations of progesterone, allopregnanolone, testosterone, 17β-estradiol, or cortisol at any tested concentration.
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Animal Model:Han Wistar (Crl:WI(Han)) (male and female)[2]
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Dosage:1,600 ppm (estimated mean intake 90.7 mg/kg/day for males, 112.6 mg/kg/day for females); 5,000 ppm (estimated mean intake 276.1 mg/kg/day for males, 362.2 mg/kg/day for females); 16,000 ppm (estimated mean intake 912.8 mg/kg/day for males, 1,208.2 mg/kg/day for females)
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Administration:p.o.; daily; 52 weeks
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Result:Ensured all rats survived the 52-week study period.
Detected no Eco-DEHCH-associated clinical or ophthalmic events.
Showed no significant differences in body weight gain and food consumption compared to control groups.
Observed statistically significant changes in red blood cell, coagulation, and urinary pH parameters that were deemed unrelated to Eco-DEHCH.
Identified no Eco-DEHCH-associated organ weight differences.
Induced minimal hyaline droplet accumulation (male rat-specific α2u-globulin accumulation) in kidneys of male rats at 5,000 and 16,000 ppm, with dose-dependent increase (5/10 rats at 5,000 ppm, 10/10 rats at 16,000 ppm).
Chemical Information
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CAS No. 84731-70-4
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분자량 396.60
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화학식 C24H44O4
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SMILES
O=C(C1CCC(CC1)C(OCC(CCCC)CC)=O)OCC(CCCC)CC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Kang J, et al. Diethyl-hexyl-cyclohexane (Eco-DEHCH) is a safer phthalate alternative that does not elicit neuroendocrine disrupting effects. Journal of hazardous materials. 2025 Jul 05;491:137947. [Content Brief]
[2]. Lee JY, et al. Evaluation of the 52-week chronic toxicity of a novel phthalate-free plasticizer, Eco-DEHCH (bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate), in Han Wistar rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jun;176:113809. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eco-DEHCH Related Classifications
HY-184780 Related Classifications
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