EIDD-036
EIDD-036, is the blood-brain barrier penetrant C-20 oxime of Progesterone (HY-N0437), that binds progesterone receptor (PR) with an IC50 of 171 nM. EIDD-036 is the active metabolite of EIDD-1723 (HY-125547). EIDD-036 exhibits promising challenges for rapid administration in acute trauma. EIDD-036 can be used for the study of traumatic brain injury (TBI).
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- CAS No.: 211302-60-2
- 화학식: C21H31NO2
- 분자량:329.48
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Parmacokinetics
In Vivo
Chemical Information
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CAS No. 211302-60-2
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분자량 329.48
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화학식 C21H31NO2
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SMILES
C[C@@]12[C@](CC[C@@H]2/C(C)=N/O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=CC(CC4)=O)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Wali B, et al. Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats. Neuropharmacology. 2016 Oct;109:148-158. [Content Brief]
[2]. Fritzemeier RG, et al. Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury. J Med Chem. 2023 Apr 27;66(8):5397-5414. [Content Brief]
[3]. Sayeed I, et al. Development of a novel progesterone analog in the treatment of traumatic brain injury. Neuropharmacology. 2019 Feb;145(Pt B):292-298. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EIDD-036 Related Classifications
HY-17649 Related Classifications
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