ERK-IN-7
ERK-IN-7 (Example 10), an analogue of SHR2415 (HY-151367), is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 2494010-63-6
- 화학식: C22H20ClN7O2
- 분자량:449.89
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
ERK1 5 nM (IC50) |
ERK2 7 nM (IC50) |
In Vitro
ERK-IN-7 (Example 10; 24 h) inhibits Colo205 proliferation with an IC50 of 62 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Colo205
-
Concentration:
-
Incubation Time:24 h
-
Result:Inhibited proliferation with an IC50 of 62 nM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57 mice[1]
-
Dosage:2 mg/kg
-
Administration:Intragastric administration (Pharmacokinetic Analysis)
-
Result:Pharmacokinetic parameters[1]
Cmax (ng/mL) AUC (ng⋅h/mL) T1/2 (h) MRT (h) CLz/F (mL/min/kg) Vz/F (mL/kg) ERK-IN-7 (Example 10) 1023 3441 3.66 3.47 9.69 3067
Chemical Information
-
CAS No. 2494010-63-6
-
분자량 449.89
-
화학식 C22H20ClN7O2
-
SMILES
O=C1N2C(CN1[C@@H](C3=CC(Cl)=CC=C3)CO)=CC(C4=NC(NC5=CC=NN5C)=NC=C4)=C2
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERK-IN-7 Related Classifications
HY-153350 Related Classifications
Powered by Bioz