Factor B-IN-6
Factor B-IN-6 is an orally active Factor B inhibitor. Factor B-IN-6 exhibits significant inhibitory activity against activation of the human serum serotonin pathway. Factor B-IN-6 can improve the severity of renal lesions and renal function, and reduce urinary protein in animal models. Factor B-IN-6 is useful for kidney disease research.
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- CAS No.: 2797066-55-6
- 화학식: C27H30F2N2O3
- 분자량:468.54
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Factor B-IN-6 (Compound 4B) has obvious inhibitory activity on the activation of human serum bypass pathway, with an IC50 of 40.7 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sheep anti-rat Fx1A serum-induced Hyman nephritis rat (7-10 weeks old, weighing 200-300 g) model[1]
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Dosage:5, 20, 60 mg/kg
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Administration:i.g., twice a day, with an interval of 8 hours, 14 days
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Result:Reduced the level of urine egg, and improved renal function.
Chemical Information
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CAS No. 2797066-55-6
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분자량 468.54
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화학식 C27H30F2N2O3
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SMILES
CC1=CC(OC)=C(C2=C1NC=C2)CN(CC[C@H](C3CC(F)(F)C3)C4)[C@@H]4C5=CC=C(C(O)=O)C=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Factor B-IN-6 Related Classifications
HY-177388 Related Classifications
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