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Cat. No.: HY-175735

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Factor XI-IN-2

Factor XI-IN-2 is a Factor XI activation inhibitor with an IC₅₀ of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus.

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CAS No.: 2563884-39-7
화학식: C₃₁H₃₁N₇O₃S
분자량:581.69

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Factor XI-IN-2 Chemical Structure

CAS No.: 2563884-39-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

Factor XI-IN-2 (Compound 7) (2 mg/kg, i.v.) reaches effective dose and observes that approximately 50% of the blood clot weight decreased. in the rabbit arteriovenous shunt thrombosis model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2563884-39-7
분자량 581.69
화학식 C₃₁H₃₁N₇O₃S
SMILES

O=C(N1CCCCC1)C2=CC(C(N3CCC(CC3)N4C=CC=N4)=O)=NC5=CC=C(C=C52)OCC6=CC=C7SN=NC7=C6
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ellsworth, Ken, et al. The Discovery of a Novel Anticoagulant Mechanism: Factor XI Activation Inhibitors. ACS Pharmacology & Translational Science (2025).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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