country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-D2318

Copy Link Print Information

Flipper-TR 5

Flipper-TR 5 is a Flipper probe containing a terminal carboxylate for retention on the plasma membrane. Flipper-TR 5 selectively labels the cytoplasmic membrane, and exhibits excellent mechanical sensitivity, negligible cytotoxicity and controllable phototoxicity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2081888-04-0
화학식: C₂₇H₂₀N₄O₅S₆
분자량:672.86

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Flipper-TR 5 Chemical Structure

CAS No.: 2081888-04-0

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Flipper-TR 5 exhibits ground-state planarization-dependent fluorescence and spectral shifts in solution and lipid bilayer membranes, with increasing red shifts, fluorescence intensity, and vibrational finestructure in increasingly ordered membranes^[1].
Flipper-TR 5 shows longer fluorescence lifetimes in more ordered Lo lipid bilayer membranes compared to Ld membranes in GUVs, with non-selective partitioning but phase-dependent fluorescence intensity^[1].
Flipper-TR 5 reports on membrane tension and organization in living cells, with fluorescence lifetimes that shift in response to hyperosmotic stress in plasma membranes, ER, and Golgi apparatus, and baseline lifetime differences driven by membrane order^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Flipper-TR 5 (direct application to embryo system) reliably reports membrane tension changes linked to ASPP2-dependent F-actin organization in mechanically stressed mouse embryo apical junctions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2081888-04-0
분자량 672.86
화학식 C₂₇H₂₀N₄O₅S₆
SMILES

CC1=C(C#N)SC(C2=C3C(C)=C(C4=C(C)C(SC5=C6SC(COCC7=CN(CC(O)=O)N=N7)=C5C)=C6S4)S2)=C1S3(=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen XX, et al. Fluorescent Flippers: Small-Molecule Probes to Image Membrane Tension in Living Systems. Angew Chem Int Ed Engl. 2023;62(20):e202217868. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기