Fludarabine-Cl
Based on 2 publication(s) in Google Scholar
Fludarabine-Cl has an inhibitory effect on RNA adenosine deaminase 1 (ADAR1) with an IC50 of 0.87 μM and can be used to prevent and/or study cancer or tumor-related diseases.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.71%
- CAS No.: 2734853-80-4
- 화학식: C10H11ClFN5O3
- 분자량:303.68
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Fludarabine-Cl
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Biological Activity
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ADAR1 0.87 μM (IC50) |
Fludarabine-Cl inhibits tumor cell proliferation, and has only a weak inhibitory effect on normal RWPE1 and HEK293 cells. The IC50 for MDA-MB-23, RPMI822, HL60 and K562 is 0.383, 0.149, 0.544 and 0.609 μM[1].
Fludarabine-Cl binds to ADAR1 protein with a KD of 7.24 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Fludarabine-Cl (10-20 mg/kg, intraperitoneal injection, twice a day, for 29 days) inhibits tumor proliferation in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice[1]
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Dosage:104.9, 131.1, 163.8, 204.8, 256, 320, 400 mg/kg; twice a day; one day
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Administration:Intraperitoneal injection (i.p.)
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Result:Was somewhat toxic and could cause death in mice at higher doses, but no abnormality in organs.
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Animal Model:BALB/c mice induced by Du-145[1]
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Dosage:10, 20 mg/kg; twice a day; 29 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited tumor growth and had no effect on mouse body weight.
Chemical Information
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CAS No. 2734853-80-4
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Appearance Solid
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분자량 303.68
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화학식 C10H11ClFN5O3
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Color White to off-white
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SMILES
NC1=C2C(N([C@]3([H])O[C@@H]([C@H]([C@H]3O)O)CCl)C=N2)=NC(F)=N1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Differ
Targeting ADAR1 lactylation activates innate immune and overcomes chemoresistance in ovarian cancer. [Abstract]2026 May 25. PMID: 42185630 -
순도&문서
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Data Sheet (276 KB)
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SDS (251 KB)
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- Deutsch - DE (251 KB)
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- Italian - IT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fludarabine-Cl Related Classifications
HY-145443 Related Classifications
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