Galegenimab
Based on 1 Customer Validation
Galegenimab (FHTR 2163) is a humanized monoclonal antibody Fab fragment targeting the HtrA1 trimer. Galegenimab is used in research on age-related macular degeneration (AMD).
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- Purity : 99.91%
- CAS No.: 2403683-24-7
- 분자량:47.71 kDa
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보관:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
Isotype
Fab IgG1 kappa
Species Reactivity
Human
IC50 & Target
HTRA1
In Vitro
As a humanized monoclonal antibody Fab fragment targeting HtrA1, Galegenimab binds to each subunit of the HtrA1 trimer with three independent Fabs to form a macromolecular complex, thereby inhibiting the protease activity of HtrA1 and blocking its proteolytic effect on extracellular matrix protein substrates such as biglycan[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Fab-G1-kappa
신청
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2403683-24-7
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Appearance Liquid
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분자량 47.71 kDa
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Color Colorless to light yellow
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SMILES
[Galegenimab]
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Synonyms
FHTR 2163; RG 6147; RO 7171009
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Jonathan B Lin, et al. Neuroprotection for Age-Related Macular Degeneration. Ophthalmol Sci. 2022 Jul 5;2(4):100192. [Content Brief]
[2]. Eichenbaum DA, et al. Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Am J Ophthalmol. 2025 Jul;275:14-26. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Galegenimab Related Classifications
HY-P99629 Related Classifications
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