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Cat. No.: HY-174393

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Gamhepathiopine

Gamhepathiopine is a thienopyrimidinone compound. Gamhepathiopine exerts antimalarial effects by targeting the Q_o site of Plasmodium falciparum cytochrome b and inhibiting the activity of complex III in the electron transport chain.

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CAS No.: 1620442-30-9
화학식: C₁₇H₁₉N₃OS
분자량:313.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Gamhepathiopine Chemical Structure

CAS No.: 1620442-30-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	CC₅₀	27.5 μM Compound: 1	Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 25791675]
Hepatocyte	CC₅₀	>200 μM Compound: 1	Cytotoxicity against cynomolgus monkey Primary hepatocyte assessed as cell viability Cytotoxicity against cynomolgus monkey Primary hepatocyte assessed as cell viability	[PMID: 36680984]
HepG2	CC₅₀	25.6 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 25791675]

Chemical Information

CAS No. 1620442-30-9
분자량 313.42
화학식 C₁₇H₁₉N₃OS
SMILES

CC1=CC=C(C2=CC(N=C(NC(C)(C)C)NC3=O)=C3S2)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wiedemar N, et al. The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b. ACS Infect Dis. 2025 Jun 13;11(6):1719-1728. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Gamhepathiopine

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Gamhepathiopine Related Classifications

HY-174393 Related Classifications