GAP-1173149
GAP-1173149 is a Chikungunya Virus polymerase inhibitor targeting the CHIKV nsP4 RNA-dependent RNA polymerase.
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- CAS No.: 1622645-58-2
- 화학식: C14H19N5O3
- 분자량:305.33
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
GAP-1173149 shows EC50 values of 15.6, 18.6, 5.3 and 11.62 μM in U-2 OS cells, Vero cells, CHIKV replicon and normal human dermal fibroblasts[1].
GAP-1173149 shows CC50 values >100 μM in U-2 OS and Vero cells, and >500 μM in normal human dermal fibroblasts[1].
GAP-1173149 (100 μM) exhibits alphavirus-specific activity, inhibiting RNA replication of CHIKV, o’nyong-nyong virus (ONNV), Ross River virus (RRV), Eastern equine encephalitis virus (EEEV) and Barmah Forest virus (BFV), while showing no inhibition on unrelated viruses (HPIV3, RSV, SARS-CoV-2, VSV) or Sindbis virus (SINV)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1622645-58-2
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분자량 305.33
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화학식 C14H19N5O3
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SMILES
O=C(NCC1=NNC2=C1CCCCC2)CN(C(NC3)=O)C3=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GAP-1173149 Related Classifications
HY-178334 Related Classifications
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