country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-189458

Copy Link Print Information

GCC-1

GCC-1 is a glycolipid. GCC-1 binds to CD1d to form a glycolipid-CD1d complex, which is presented to cellular TCR, thereby activating cells in a CD1d-dependent manner. GCC-1 induces Th1-biased cellular activation and IFN-γ production. GCC-1 can be used for research on colon adenocarcinoma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₅₂H₉₃NO₁₀
분자량:892.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

GCC-1 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

CD1d

In Vitro

Innate ImmunityAdaptive Immunity

Innate Immunity

Adaptive Immunity

GCC-1 (100 nM; 2-24 h) is more efficiently presented and persists longer on the surface of DC2.4 cells than αGalCer via CD1d-mediated antigen presentation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityAdaptive ImmunityCytokines & ChemokinesAnti-cancer

Innate Immunity

Adaptive Immunity

Cytokines & Chemokines

Anti-cancer

GCC-1 (i.p.; single injection) more effectively activates innate immune responses in mice and enhances the synergistic activation of NKT and NK cells^[1].

Anti-cancer

GCC-1 (1 nmol; i.v.; on days 3 and 10) induces potent antitumor activity, reducing tumor volume to approximately 1000 mm³ and prolonging survival^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice^[1]
Dosage:

1 nmol
Administration:

i.v.; on days 3 and 10
Result:

Reduced average tumor volume to approximately 1000 mm³ on day 30, whereas control groups exhibited tumor volumes close to 2000 mm³.
Significantly prolonged survival relative to αGalCer.

Related Protocols :

Naïve CD4+ T-cell subset differentiation/polarization

Chemical Information

분자량 892.30
화학식 C₅₂H₉₃NO₁₀
SMILES

OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@@H]1OC[C@H](NC(CC2=CC=C(OCC3CCCCCCCCCCCCCCCCCC3)C=C2)=O)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Sun Q N, et al. All-Hydrocarbon Macrocycle Enables Highly Potent Th1-Biased NKT Cell Agonists for Immunotherapy[J]. JACS Au.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기