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Cat. No.: HY-118120

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GEMSA

Name: GEMSA
Brand: MedChemExpress
SKU: HY-118120
Price: 485.00 USD
Availability: PreOrder

(Synonyms: 2-Guanidinoethylmercaptosuccinic acid)

GEMSA is a potent inhibitor of enkephalin convertase (K_i=8.8 nM). GEMSA elicites analgesia.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98%
CAS No.: 77482-44-1
화학식: C₇H₁₃N₃O₄S
분자량:235.26

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

GEMSA Chemical Structure

CAS No.: 77482-44-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

GEMSA is a potent inhibitor of enkephalin convertase (K_i=8.8 nM). GEMSA elicites analgesia^[1].

IC₅₀ & Target

Encephalin convertase, K_i 值为8.8 nM.

In Vitro

GEMSA inhibits the activation of TAFI and porcine CBB^[1].
GEMSA can inhibit the prolongation of lysis time in recombinant BAP and does not lead to the lysis of APC fibronectin^[1].
GEMSA inhibits the prolongation of lysis time in porcine CPB, TAFI, and recombinant BAP, APC with the EC₅₀ values of 0.34 μM, 100μM, 115 μM, 90 μM respectively^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GEMSA (ICV, 0.1μg/mg, every, 3days) results in a 75% increase in hypothalamic luteinizing hormone-releasing hormone and serum luteinizing hormone levels, and a 60% decrease in serum prolactin concentrations in rat^[3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 77482-44-1
Appearance Solid
분자량 235.26
화학식 C₇H₁₃N₃O₄S
Color White to off-white
SMILES

OC(C(SCCNC(N)=N)CC(O)=O)=O
Synonyms

2-Guanidinoethylmercaptosuccinic acid
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. B Przewlocka, et al. Analgesic and convulsant effects of guanidinoethylmercaptosuccinic acid (GEMSA)--a potent enkephalin convertase inhibitor. Neuropeptides. Nov-Dec 1986;8(4):359-65. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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GEMSA

2-PMPA

2-MPPA

2-PMPA (Standard)

2-MPPA (Standard)

ZJ43

Mergetpa

2-Benzylsuccinic acid

CPA inhibitor

Carboxypeptidase G2 (CPG2) Inhibitor

GCPII-IN-1 TFA

2-Benzylsuccinic acid (Standard)

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

GEMSA

2-PMPA

2-MPPA

2-PMPA (Standard)

2-MPPA (Standard)

ZJ43

Mergetpa

2-Benzylsuccinic acid

CPA inhibitor

Carboxypeptidase G2 (CPG2) Inhibitor

GCPII-IN-1 TFA

2-Benzylsuccinic acid (Standard)

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GEMSA Related Classifications

HY-118120 Related Classifications

Bioz