NPM3 - nucleophosmin/nucleoplasmin 3 Gene

Also Known as PORMIN; TMEM123

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10360

About NPM3

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,781,325-101,783,446 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 11.1), appendix (RPKM 9.9) and 25 other tissues.

Summary

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]

NPM3 Products (1)

mRNA Protein Name
NM_006993.3 NP_008924.1 nucleoplasmin-3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22190034 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPM3 Protein Structure

Nucleoplasmin

Nucleoplasmin: Nucleoplasmin/nucleophosmin domain (34 - 163)

  • 0
  • 100
  • 178 a.a.
Protein Preferred Names Protein Names

nucleoplasmin-3

  • nucleophosmin/nucleoplasmin family, member 3

NPM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NPM3 O75607 UPRT Homo sapiens Q96BW1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NPM3 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P83865 NPM3 Antibody (YA3562) IHC-P, ICC/IF, FC, ELISA Human, Mouse
HY-P83865A NPM3 Antibody (YA3562)(PBS only) IHC-P, ICC/IF, FC, ELISA Human, Mouse

Related Diseases

Diseases Alias
Lung Papillary Adenocarcinoma

  • Papillary Lung Adenocarcinoma

  • Papillary Adenocarcinoma Of The Lung
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS09492 NPM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NPM3 RGD RGD:1565542
Felis catus NPM3 VGNC VGNC:97534
Mus musculus NPM3 MGD MGI:894653
Bos taurus NPM3 VGNC VGNC:32208
Macaca mulatta NPM3 VGNC VGNC:75385
Canis familiaris NPM3 VGNC VGNC:43923
Others NPM3 NCBI