TBCEL - tubulin folding cofactor E like Gene

Also Known as El; LRRC35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 219899

About TBCEL

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:121,024,102-121,090,776 (from NCBI)

This gene has 10 transcripts (splice variants), 283 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 8.9), thyroid (RPKM 6.7) and 25 other tissues.

Summary

Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule Cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in Cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TBCEL Products (3)

mRNA	Protein	Name
NM_001130047.3	NP_001123519.1	tubulin-specific chaperone cofactor E-like protein
NM_001363644.2	NP_001350573.1	tubulin-specific chaperone cofactor E-like protein
NM_152715.5	NP_689928.3	tubulin-specific chaperone cofactor E-like protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBCEL Protein Structure

Ubiquitin_2

0
100
200
300
400
424 a.a.

Protein Preferred Names	Protein Names
tubulin-specific chaperone cofactor E-like protein	E-like

TBCEL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TBCEL	Q5QJ74	LBX1	Homo sapiens	P52954	Y2H Prey Pooling	32296183
Intra	TBCEL	Q5QJ74	LBX1	Homo sapiens	P52954	Y2H Array	32296183
Intra	TBCEL	Q5QJ74	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	TBCEL	Q5QJ74	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	TBCEL	Q5QJ74	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	TBCEL	Q5QJ74	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	TBCEL	Q5QJ74	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	TBCEL	Q5QJ74	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	TBCEL	Q5QJ74	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
Intra	TBCEL	Q5QJ74	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b	Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a	MLC2A Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS14255	TBCEL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TBCEL	VGNC	VGNC:35654
Rattus norvegicus	TBCEL	RGD	RGD:1308880
Mus musculus	TBCEL	MGD	MGI:1925543
Canis familiaris	TBCEL	VGNC	VGNC:47158
Felis catus	TBCEL	VGNC	VGNC:99691
Others	TBCEL	NCBI