IGFBP6 - insulin like growth factor binding protein 6 Gene
Also Known as IBP6
Species: Homo sapiens
About IGFBP6
This gene has 5 transcripts (splice variants), 242 orthologues and 5 paralogues. Broad expression in fat (RPKM 60.7), prostate (RPKM 49.9) and 17 other tissues.
Summary
Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy. [provided by Alliance of Genome Resources, Apr 2022]
IGFBP6 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002178.3 | NP_002169.1 | insulin-like growth factor-binding protein 6 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| enables insulin-like growth factor II binding |
IMP
IMP: Inferred from mutant phenotype
|
15308688 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
24003225 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cell migration |
IDA
IDA: Inferred from direct assay
|
24003225 | GOA |
| involved in positive regulation of MAPK cascade |
IDA
IDA: Inferred from direct assay
|
24003225 | GOA |
| involved in positive regulation of stress-activated MAPK cascade |
IDA
IDA: Inferred from direct assay
|
24003225 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of insulin-like growth factor binary complex |
IMP
IMP: Inferred from mutant phenotype
|
15308688 | GOA |
IGFBP6 Protein Structure
IGFBP: Insulin-like growth factor binding protein (29 - 84)
Thyroglobulin_1: Thyroglobulin type-1 repeat (163 - 234)
- 0
- 100
- 200
- 240 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
insulin-like growth factor-binding protein 6 |
|
IGFBP6 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
IGFBP6 | P24592 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | CREB5 | Homo sapiens | Q02930-3 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | CCDC28A | Homo sapiens | Q7Z6N9 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | KRTAP5-7 | Homo sapiens | Q6L8G8 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | KRTAP5-7 | Homo sapiens | Q6L8G8 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | KRTAP5-7 | Homo sapiens | Q6L8G8 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | C1orf74 | Homo sapiens | Q96LT6 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | PLEKHA7 | Homo sapiens | Q6IQ23-2 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | ANKRD11 | Homo sapiens | X5D778 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | POU4F2 | Homo sapiens | Q12837 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | RANBP10 | Homo sapiens | Q6VN20 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | KRTAP5-9 | Homo sapiens | P26371 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | KRTAP5-9 | Homo sapiens | P26371 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | KRTAP5-9 | Homo sapiens | P26371 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | RABGGTB | Homo sapiens | P53611 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | RABGGTB | Homo sapiens | P53611 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | RABGGTB | Homo sapiens | P53611 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | EFEMP1 | Homo sapiens | Q12805 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | ZNF587 | Homo sapiens | Q96SQ5 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | ZNF417 | Homo sapiens | Q8TAU3 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | CCDC116 | Homo sapiens | Q8IYX3 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | AQP1 | Homo sapiens | P29972 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | UBAC1 | Homo sapiens | Q9BSL1 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | NCALD | Homo sapiens | P61601 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | SMCP | Homo sapiens | P49901 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | SMCP | Homo sapiens | P49901 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | SMCP | Homo sapiens | P49901 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | EPDR1 | Homo sapiens | Q9UM22 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
IGFBP6 | P24592 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 |
Recombinant IGFBP6 Proteins
| Cat. No. | 상품명 | Accession | Purity |
|---|---|---|---|
| HY-P73141 | IGFBP-6 Protein, Human (HEK293, His) | P24592 (R28-G240) | ≥ 95%, as determined by reducing SDS-PAGE. |
IGFBP6 Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P83331 | IGFBP6 Antibody (YA3076) | WB | Human |
| HY-P83331A | IGFBP6 Antibody (YA3076)(PBS only) | WB | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| In Situ Carcinoma |
|
|
| Insulin-Like Growth Factor I |
|
|
| Acth-Secreting Pituitary Adenoma |
|
|
| Vitreoretinopathy |
|
|
| Rhabdomyosarcoma |
|
|
| Sotos Syndrome |
|
|
| Renal Osteodystrophy |
|
|
| Osteogenic Sarcoma |
|
|
| Middle Cerebral Artery Infarction |
|
|
| Breast Cancer |
|
|
| Pheochromocytoma |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | IGFBP6 | VGNC | VGNC:108351 |
| Canis familiaris | IGFBP6 | VGNC | VGNC:41907 |
| Mus musculus | IGFBP6 | MGD | MGI:96441 |
| Bos taurus | IGFBP6 | VGNC | VGNC:30088 |
| Felis catus | IGFBP6 | VGNC | VGNC:67716 |
| Rattus norvegicus | IGFBP6 | RGD | RGD:2877 |
| Others | IGFBP6 | NCBI |