MINK1 - misshapen like kinase 1 Gene

Also Known as B55; ZC3; MINK; YSK2; MAP4K6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50488

About MINK1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,833,340-4,898,061 (from NCBI)

This gene has 14 transcripts (splice variants), 204 orthologues and 35 paralogues. Ubiquitous expression in skin (RPKM 48.7), brain (RPKM 31.3) and 25 other tissues.

Summary

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]

MINK1 Products (29)

mRNA Protein Name
XM_047436173.1 XP_047292129.1 misshapen-like kinase 1 isoform X17
XM_006721532.2 XP_006721595.1 misshapen-like kinase 1 isoform X2
XM_017024706.1 XP_016880195.1 misshapen-like kinase 1 isoform X12
NM_170663.5 NP_733763.1 misshapen-like kinase 1 isoform 2
XM_006721536.2 XP_006721599.1 misshapen-like kinase 1 isoform X11
XM_047436175.1 XP_047292131.1 misshapen-like kinase 1 isoform X19
XM_017024704.1 XP_016880193.1 misshapen-like kinase 1 isoform X3
XM_047436179.1 XP_047292135.1 misshapen-like kinase 1 isoform X24
NM_153827.5 NP_722549.2 misshapen-like kinase 1 isoform 3
XM_011523906.1 XP_011522208.1 misshapen-like kinase 1 isoform X9
XM_047436174.1 XP_047292130.1 misshapen-like kinase 1 isoform X18
NM_001321236.2 NP_001308165.1 misshapen-like kinase 1 isoform 5
XM_017024705.1 XP_016880194.1 misshapen-like kinase 1 isoform X5
XM_047436170.1 XP_047292126.1 misshapen-like kinase 1 isoform X13
XM_047436178.1 XP_047292134.1 misshapen-like kinase 1 isoform X23
XM_047436169.1 XP_047292125.1 misshapen-like kinase 1 isoform X10
XM_047436168.1 XP_047292124.1 misshapen-like kinase 1 isoform X8
NM_015716.5 NP_056531.1 misshapen-like kinase 1 isoform 1
XM_017024707.3 XP_016880196.1 misshapen-like kinase 1 isoform X16
XM_047436171.1 XP_047292127.1 misshapen-like kinase 1 isoform X14
XM_047436167.1 XP_047292123.1 misshapen-like kinase 1 isoform X7
XM_047436172.1 XP_047292128.1 misshapen-like kinase 1 isoform X15
XM_047436176.1 XP_047292132.1 misshapen-like kinase 1 isoform X21
XM_047436177.1 XP_047292133.1 misshapen-like kinase 1 isoform X22
XM_017024708.2 XP_016880197.1 misshapen-like kinase 1 isoform X20
NM_001024937.4 NP_001020108.1 misshapen-like kinase 1 isoform 4
XM_047436165.1 XP_047292121.1 misshapen-like kinase 1 isoform X4
XM_006721531.2 XP_006721594.1 misshapen-like kinase 1 isoform X1
XM_047436166.1 XP_047292122.1 misshapen-like kinase 1 isoform X6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15469942 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18930710 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15469942 GOA
NOT involved in microvillus assembly IMP
IMP: Inferred from mutant phenotype
22797597 GOA
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
15469942 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
15469942 GOA
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21690388 GOA
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
15469942 GOA
involved in regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15469942 GOA
involved in regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
15469942 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15469942 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18930710 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MINK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (25 - 289)

CNH

CNH: CNH domain (1024 - 1302)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1332 a.a.
Protein Preferred Names Protein Names

misshapen-like kinase 1

  • GCK family kinase MINK

  • MAPK/ERK kinase kinase kinase 6

  • MEK kinase kinase 6

  • MEKKK 6

  • misshapen/NIK-related kinase

  • mitogen-activated protein kinase kinase kinase kinase 6

MINK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MINK1 Q8N4C8 MAP4K4 Homo sapiens O95819
Anti Tag CoIP
25852190
Intra
MINK1 Q8N4C8 MAP4K4 Homo sapiens O95819
Pull Down
32707033
Intra
MINK1 Q8N4C8 MAP4K4 Homo sapiens O95819
Anti Tag CoIP
33961781
Intra
MINK1 Q8N4C8 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
MINK1 Q8N4C8 RAP2A Homo sapiens P10114
Y2H
18930710
Intra
MINK1 Q8N4C8 HSF1 Homo sapiens Q00613
Pull Down
25816751
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alzheimer Disease 15

  • AD15

  • Alzheimer'S Disease 15

  • Alzheimer Disease Without Neurofibrillary Tangles

  • Alzheimer'S Disease 15, Late Onset

  • Alzheimer'S Disease Without Neurofibrillary Tangles
Conjunctival Folliculosis

  • Acute Follicular Conjunctivitis
Shipyard Eye

  • Epidemic Keratoconjunctivitis

  • Ekc
Long Qt Syndrome

  • Romano-Ward Syndrome

  • Long Q-T Syndrome

  • Lqt

  • Qt Syndrome, Long

  • Congenital Long Qt Syndrome

  • Familial Long Qt Syndrome
Acute Hemorrhagic Conjunctivitis

  • Viral Conjunctivitis

  • Conjunctivitis, Acute Hemorrhagic

  • Apollo Disease

  • Epidemic Hemorrhagic Conjunctivitis

  • Viral Conjunctiva Disorder

  • Viral Conjunctivitis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-17437A Mefloquine hydrochloride 99.98% Yes
HY-17437 Mefloquine 99.79% Yes

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-111754 DMX-5804 Inhibitor 99.64% Unkown
HY-108591 L-364,373 Activator 99.65% Unkown
HY-RS08454 MINK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08455 Mink1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08456 Mink1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W402208 MAP4K4-IN-7 Inhibitor / Unkown
HY-178775 PI4K-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MINK1 VGNC VGNC:81475
Canis familiaris MINK1 VGNC VGNC:53424
Felis catus MINK1 VGNC VGNC:97509
Mus musculus MINK1 MGD MGI:1355329
Bos taurus MINK1 VGNC VGNC:31479
Rattus norvegicus MINK1 RGD RGD:1359135
Others MINK1 NCBI