RAB22A - RAB22A, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57403

About RAB22A

Cytogenetic location: 20q13.32 Genomic coordinates (GRCh38): 20:58,309,715-58,367,507 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 7.8), adrenal (RPKM 6.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]

RAB22A Products (1)

mRNA Protein Name
NM_020673.3 NP_065724.1 ras-related protein Rab-22A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
20937701 GOA
enables GTP binding IMP
IMP: Inferred from mutant phenotype
24466322 GOA
enables GTPase activity IMP
IMP: Inferred from mutant phenotype
24466322 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11870209 GOA
Biological Process GO Annotation Evidence References Source
involved in endocytosis IDA
IDA: Inferred from direct assay
11870209 GOA
involved in endosome organization IEP
IEP: Inferred from expression pattern
11870209 GOA
involved in regulation of vesicle size IMP
IMP: Inferred from mutant phenotype
24466322 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
11870209 GOA
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
21255211 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11870209 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB22A Protein Structure

Ras

Ras: Ras family (7 - 166)

  • 0
  • 100
  • 194 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-22A

  • GTP-binding protein RAB22A

RAB22A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAB22A Q9UL26 ALS2CL Homo sapiens Q60I27
Y2H Array
32296183
Intra
RAB22A Q9UL26 ALS2CL Homo sapiens Q60I27
Y2H Prey Pooling
32296183
Intra
RAB22A Q9UL26 EEA1 Homo sapiens Q15075
Y2H
11870209
Intra
RAB22A Q9UL26 APPL2 Homo sapiens Q8NEU8
Y2H Array
31515488
Intra
RAB22A Q9UL26 APPL2 Homo sapiens Q8NEU8
Validated Y2H
25416956
Intra
RAB22A Q9UL26 APPL2 Homo sapiens Q8NEU8
Y2H Prey Pooling
32296183
Intra
RAB22A Q9UL26 APPL2 Homo sapiens Q8NEU8
Y2H Array
25416956
Intra
RAB22A Q9UL26 APPL2 Homo sapiens Q8NEU8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RAB22A Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P82046 Rab22A Antibody (YA1791) WB, ICC/IF, IP Human, Mouse, Rat
HY-P82046A Rab22A Antibody (YA1791)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Exocervical Carcinoma

  • Carcinoma Of Exocervix

  • Carcinoma Of The Exocervix
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS11532 RAB22A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RAB22A VGNC VGNC:45262
Rattus norvegicus RAB22A RGD RGD:1311959
Macaca mulatta RAB22A VGNC VGNC:81522
Bos taurus RAB22A VGNC VGNC:33629
Mus musculus RAB22A MGD MGI:105072
Others RAB22A NCBI