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TIAM1 - TIAM Rac1 associated GEF 1 Gene

Also Known as NEDLDS; TIAM-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7074

About TIAM1

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:31,118,418-31,559,087 (from NCBI)

This gene has 8 transcripts (splice variants), 284 orthologues and 22 paralogues. Broad expression in esophagus (RPKM 7.7), skin (RPKM 6.8) and 23 other tissues.

Summary

This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]

TIAM1 Products (12)

mRNA	Protein	Name
NM_001353684.2	NP_001340613.1	rho guanine nucleotide exchange factor TIAM1 isoform 2
NM_001353685.2	NP_001340614.1	rho guanine nucleotide exchange factor TIAM1 isoform 3
NM_001353686.2	NP_001340615.1	rho guanine nucleotide exchange factor TIAM1 isoform 4
NM_001353687.2	NP_001340616.1	rho guanine nucleotide exchange factor TIAM1 isoform 5
NM_001353688.1	NP_001340617.1	rho guanine nucleotide exchange factor TIAM1 isoform 1
NM_001353689.1	NP_001340618.1	rho guanine nucleotide exchange factor TIAM1 isoform 1
NM_001353690.1	NP_001340619.1	rho guanine nucleotide exchange factor TIAM1 isoform 1
NM_001353691.1	NP_001340620.1	rho guanine nucleotide exchange factor TIAM1 isoform 1
NM_001353692.1	NP_001340621.1	rho guanine nucleotide exchange factor TIAM1 isoform 1
NM_001353693.1	NP_001340622.1	rho guanine nucleotide exchange factor TIAM1 isoform 1
NM_001353694.2	NP_001340623.1	rho guanine nucleotide exchange factor TIAM1 isoform 1
NM_003253.3	NP_003244.2	rho guanine nucleotide exchange factor TIAM1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	EXP EXP: Inferred from Experiment	15721239	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	23109420	GOA
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	20361982	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	23109420	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17440041	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Rac protein signal transduction	IDA IDA: Inferred from direct assay	25032858	GOA
involved in Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	20361982	GOA
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	23109420	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20361982	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	20361982	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	25032858	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	25032858	GOA
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	23109420	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	23109420	GOA
involved in regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	20826792	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	20361982	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	20332120	GOA
located in cytosol	IDA IDA: Inferred from direct assay	23109420	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23109420	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIAM1 Protein Structure

RBD

PDZ

RhoGEF

0
300
600
900
1200
1500
1591 a.a.

Protein Preferred Names	Protein Names
rho guanine nucleotide exchange factor TIAM1	T cell lymphoma invasion and metastasis 1

TIAM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TIAM1	Q13009	CASK	Homo sapiens	O14936	Y2H Fragment Pooling	35914814
Intra	TIAM1	Q13009	CNTNAP4	Homo sapiens	Q9C0A0-1	NMR	23395182
Intra	TIAM1	Q13009	CNTNAP4	Homo sapiens	Q9C0A0-1	ITC	23395182
Intra	TIAM1	Q13009	SDC1	Homo sapiens	P18827	X-Ray Diffraction	23395182
Intra	TIAM1	Q13009	SDC1	Homo sapiens	P18827	ITC	23395182
Intra	TIAM1	Q13009	SDC1	Homo sapiens	P18827	Fluorescence Spectr	23395182
Intra	TIAM1	Q13009	SDC1	Homo sapiens	P18827	NMR	23395182

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Language Delay And Seizures	NEDLDS
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Quadriplegia	Tetraplegia Tetraplegias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis	Neutrophil Immunodeficiency Syndrome IMD73A Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis Rac 2 Deficiency
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-16659	EHT 1864	Inhibitor	99.85%	Unkown
HY-104064	1A-116		99.72%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-P1382A	Rac1 Inhibitor W56 TFA	Inhibitor	99.92%	Unkown
HY-171977	UTKO1	Inhibitor	/	Unkown
HY-P1382	Rac1 Inhibitor W56	Inhibitor	/	Unkown
HY-RS14515	TIAM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18300	Tiam1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24778	Tiam1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TIAM1	VGNC	VGNC:56122
Bos taurus	TIAM1	VGNC	VGNC:56334
Felis catus	TIAM1	VGNC	VGNC:82570
Mus musculus	TIAM1	MGD	MGI:103306
Rattus norvegicus	TIAM1	RGD	RGD:1307455
Macaca mulatta	TIAM1	VGNC	VGNC:81886
Others	TIAM1	NCBI