CFLAR - CASP8 and FADD like apoptosis regulator Gene
Also Known as CASH; FLIP; MRIT; CLARP; FLAME; cFLIP; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1
Species: Homo sapiens
About CFLAR
This gene has 24 transcripts (splice variants), 219 orthologues and 16 paralogues. Ubiquitous expression in fat (RPKM 11.3), bone marrow (RPKM 9.5) and 25 other tissues.
Summary
The protein encoded by this gene is a regulator of Apoptosis and is structurally similar to Caspase-8. However, the encoded protein lacks Caspase activity and appears to be itself cleaved into two peptides by Caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
CFLAR Products (15)
| mRNA | Protein | Name |
|---|---|---|
| NM_001127183.4 | NP_001120655.1 | CASP8 and FADD-like apoptosis regulator isoform 1 |
| NM_001127184.4 | NP_001120656.1 | CASP8 and FADD-like apoptosis regulator isoform 2 |
| NM_001202515.1 | NP_001189444.1 | CASP8 and FADD-like apoptosis regulator isoform 3 |
| NM_001202516.3 | NP_001189445.1 | CASP8 and FADD-like apoptosis regulator isoform 4 |
| NM_001202517.3 | NP_001189446.1 | CASP8 and FADD-like apoptosis regulator isoform 5 |
| NM_001202518.2 | NP_001189447.1 | CASP8 and FADD-like apoptosis regulator isoform 6 |
| NM_001202519.3 | NP_001189448.1 | CASP8 and FADD-like apoptosis regulator isoform 6 |
| NM_001308042.3 | NP_001294971.1 | CASP8 and FADD-like apoptosis regulator isoform 7 |
| NM_001308043.2 | NP_001294972.1 | CASP8 and FADD-like apoptosis regulator isoform 8 |
| NM_001351590.2 | NP_001338519.1 | CASP8 and FADD-like apoptosis regulator isoform 7 |
| NM_001351591.2 | NP_001338520.1 | CASP8 and FADD-like apoptosis regulator isoform 2 |
| NM_001351592.2 | NP_001338521.1 | CASP8 and FADD-like apoptosis regulator isoform 2 |
| NM_001351593.2 | NP_001338522.1 | CASP8 and FADD-like apoptosis regulator isoform 5 |
| NM_001351594.2 | NP_001338523.1 | CASP8 and FADD-like apoptosis regulator isoform 5 |
| NM_003879.7 | NP_003870.4 | CASP8 and FADD-like apoptosis regulator isoform 1 |
CFLAR Protein Structure
DED: Death effector domain (4 - 79)
DED: Death effector domain (93 - 175)
Peptidase_C14: Caspase domain (262 - 461)
- 0
- 100
- 200
- 300
- 400
- 480 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
CASP8 and FADD-like apoptosis regulator |
|
CFLAR Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CFLAR | O15519 | TRAF1 | Homo sapiens | Q13077 | 32296183 | |
|
Intra
|
CFLAR | O15519 | TRAF1 | Homo sapiens | Q13077 | 25416956 | |
|
Intra
|
CFLAR | O15519 | TRAF1 | Homo sapiens | Q13077 | 32296183 | |
|
Intra
|
CFLAR | O15519 | TRAF1 | Homo sapiens | Q13077 | 25416956 | |
|
Intra
|
CFLAR | O15519 | TRAF1 | Homo sapiens | Q13077 | 25416956 | |
|
Intra
|
CFLAR | O15519 | TRAF1 | Homo sapiens | Q13077 | 32296183 | |
|
Intra
|
CFLAR | O15519 | CASP10 | Homo sapiens | Q92851 | 23541952 | |
|
Intra
|
CFLAR | O15519 | CASP8 | Homo sapiens | Q14790 | 17047155 | |
|
Intra
|
CFLAR | O15519 | CASP8 | Homo sapiens | Q14790 | 33961781 |
CFLAR Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P83834 | CFLAR Antibody (YA3531) | WB, IHC-P, FC, ELISA | Human, Mouse |
| HY-P83834A | CFLAR Antibody (YA3531)(PBS only) | WB, IHC-P, FC, ELISA | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1 |
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| Colorectal Cancer |
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| Lymphoma |
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| Colon Adenocarcinoma |
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| B-Cell Lymphoma |
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| Caspase 8 Deficiency |
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| Ewing Sarcoma |
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| Lymphoma, Hodgkin, Classic |
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| Myelodysplastic Syndrome |
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| Prostate Cancer |
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| Cholangiocarcinoma |
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| Lung Cancer |
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| High Grade Glioma |
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| Endometrial Cancer |
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| Ovarian Cancer |
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| Bladder Cancer |
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| Pancreatic Cancer |
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| Follicular Lymphoma |
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| Basal Cell Carcinoma |
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| Ectodermal Dysplasia |
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| Gastric Cancer |
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| Multiple Sclerosis |
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| Hepatocellular Carcinoma |
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| Leukemia, Chronic Lymphocytic |
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| Melanoma |
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| Alopecia, Androgenetic, 1 |
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| Myeloma, Multiple |
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| Lymphoma, Non-Hodgkin, Familial |
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| Autoimmune Lymphoproliferative Syndrome |
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| Renal Cell Carcinoma, Nonpapillary |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | CFLAR | VGNC | VGNC:71019 |
| Felis catus | CFLAR | VGNC | VGNC:60828 |
| Bos taurus | CFLAR | VGNC | VGNC:27255 |
| Rattus norvegicus | CFLAR | RGD | RGD:620847 |
| Canis familiaris | CFLAR | VGNC | VGNC:39178 |
| Mus musculus | CFLAR | MGD | MGI:1336166 |
| Others | CFLAR | NCBI |