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GFPT2 - glutamine-fructose-6-phosphate transaminase 2 Gene

Also Known as GFAT; GFAT2; GFAT 2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9945

About GFPT2

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:180,300,698-180,353,336 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 1 paralogue. Broad expression in appendix (RPKM 10.6), gall bladder (RPKM 9.6) and 23 other tissues.

Summary

Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; and protein N-linked glycosylation. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in cytosol. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]

GFPT2 Products (1)

mRNA	Protein	Name
NM_005110.4	NP_005101.1	glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IDA IDA: Inferred from direct assay	35229715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in UDP-N-acetylglucosamine biosynthetic process	IDA IDA: Inferred from direct assay	35229715	GOA
involved in fructose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	35229715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFPT2 Protein Structure

GATase_2

SIS

0
200
400
600
682 a.a.

Protein Preferred Names	Protein Names
glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	D-fructose-6-phosphate amidotransferase 2

GFPT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GFPT2	O94808	GFPT1	Homo sapiens	Q06210	Anti Tag CoIP	33961781
Intra	GFPT2	O94808	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

GFPT2 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P83169	GFPT2 Antibody (YA2914)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P83169A	GFPT2 Antibody (YA2914)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Alzheimer Disease 19	AD19 Alzheimer'S Disease 19 Alzheimer Disease 19, Late-Onset Alzheimer Disease 19 Late Onset Late-Onset Alzheimer Disease Alzheimer Disease, Late Onset, Susceptibility To, Type 19 Alzheimer Disease, Late Onset
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS05385	GFPT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19199	Gfpt2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25687	Gfpt2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GFPT2	RGD	RGD:1303097
Felis catus	GFPT2	VGNC	VGNC:62528
Bos taurus	GFPT2	VGNC	VGNC:29331
Canis familiaris	GFPT2	VGNC	VGNC:41188
Mus musculus	GFPT2	MGD	MGI:1338883
Macaca mulatta	GFPT2	VGNC	VGNC:72916
Others	GFPT2	NCBI