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United States

Product Name	Size / Unit Price	Qty

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Cat. No.: HY-175448

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GNE-1567

GNE-1567 is a potent ERα PROTAC degrader and a selective XIAP antagonist with a K_d value of 0.03 μM. GNE-1567 is indicated for breast cancer research.
(Pink: ERα ligand (HY-18719); Blue: XIAP ligand (HY-175449); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₆₀H₆₅BrN₆O₉
분자량:1094.10

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

GNE-1567 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

GNE-1567 is a potent ERα PROTAC degrader and a selective XIAP antagonist with a K_d value of 0.03 μM. GNE-1567 is indicated for breast cancer research^[1]. (Pink: ERα ligand (HY-18719); Blue: XIAP ligand (HY-175449); Black: linker).

IC₅₀ & Target

XIAP

0.03 μM (Kd)

All PROTACs Isoforms :

All Estrogen Receptor/ERR Isoforms :

All IAP Isoforms :

Chemical Information

분자량 1094.10
화학식 C₆₀H₆₅BrN₆O₉
SMILES

CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(C=C3)OCCN(C(CCOCCOCCC(N4C5=C(N(C([C@H]([C@@H]4C)NC([C@@H](NC)C)=O)=O)CC6=C(C=CC7=C6C=CC(Br)=C7)OC)C=CC(C#N)=C5)=O)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shemorry A, et al. Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases. Cell Chem Biol. 2025 May 15;32(5):694-709.e35. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

GNE-1567

All PROTACs Isoforms

All Estrogen Receptor/ERR Isoforms

All IAP Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GNE-1567 Related Classifications

HY-175448 Related Classifications