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Cat. No.: HY-171172

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GSC-718

GSC-718 is a CD22 inhibitor with an IC₅₀ of 0.161 μM against mouse CD22. GSC-718 competitively blocks the binding of mouse CD22 to natural glycan ligands, and inhibits the interaction between CD22 and α2,6-sialylated ligands. GSC-718 promotes B cell proliferation and enhances antibody production. GSC-718 can be used in the research of B cell lymphoma and rheumatoid arthritis.

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CAS No.: 2493080-16-1
화학식: C₃₂H₃₅N₂NaO₁₁
분자량:646.62

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

GSC-718 Chemical Structure

CAS No.: 2493080-16-1

Amount: USD 0.00

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

In Vitro

GSC-718 (2 hours) potently inhibits recombinant mouse CD22-Fc binding to biotinylated sialoside 71 in a competitive ELISA with an IC₅₀ of 0.161 µM^[1].
GSC-718 significantly enhances B cell proliferation induced by various stimuli including toll-like receptor ligands^[1].
GSC-718 (10-100 μM; 10 min) partially inhibits proximity labeling of CD22-associated proteins on wild-type mouse spleen B cells, while GSC-932 achieves near-complete inhibition under the same conditions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2493080-16-1
분자량 646.62
화학식 C₃₂H₃₅N₂NaO₁₁
SMILES

O=C(O[Na])[C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(CO)=O)([H])[C@H](O)[C@H](O)CNC(CC2=CC=C(C3=CC=C(C=C3)O)C=C2)=O)OCC4=CC=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Suganuma Y, et al. Improved synthesis of CD22-binding sialosides and its application for further development of potent CD22 inhibitors. Glycoconjugate journal. 2023 Apr;40(2):225-246. [Content Brief]

[2]. Alborzian Deh Sheikh A, et al. Analysis of CD22 cis-ligands using a synthetic sialoside binding to CD22 with ultra-high affinity. Carbohydrate research. 2025 Aug;554:109519.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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