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Cat. No.: HY-155024

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HAT-IN-8

HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis.

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CAS No.: 3036127-14-4
화학식: C₁₄H₁₅F₂N₃O₂S
분자량:327.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HAT-IN-8 Chemical Structure

CAS No.: 3036127-14-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis^[1].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	EC₅₀	46 μM Compound: 38	Antiproliferative activity against human MRC5 cells in presence of 5% Co2 incubated for 69 hrs followed by resazurin addition further incubated for 4 hrs Antiproliferative activity against human MRC5 cells in presence of 5% Co2 incubated for 69 hrs followed by resazurin addition further incubated for 4 hrs	[PMID: 37343180]

Chemical Information

CAS No. 3036127-14-4
분자량 327.35
화학식 C₁₄H₁₅F₂N₃O₂S
SMILES

CC(C)(O)CC(C1=C(N)N=C(NC2=CC=C(F)C(F)=C2)S1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cleghorn LAT, et al. Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues. J Med Chem. 2023 Jul 13;66(13):8896-8916. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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HAT-IN-8

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HAT-IN-8 Related Classifications

HY-155024 Related Classifications