Histargin
Histargin is a selective carboxypeptidase B inhibitor with an IC50 of 17 μg/mL and a Ki of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 93361-66-1
- 화학식: C14H25N7O4
- 분자량:355.39
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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carboxypeptidase B 17 μg/mL (IC50) |
carboxypeptidase B 30 μM (Ki) |
Histargin monohydrate (30 min) potently and competitively inhibits purified bovine carboxypeptidase B with an IC50 of 17 μg/mL and a Ki of 3.2 × 10-5 M, and this inhibitory activity is dependent on metal chelation, being blocked by specific divalent metal cations[1].
Histargin does not inhibit purified carboxypeptidase A, aminopeptidase A (IC50 >100 μg/mL)[1].
Histargin lacks antimicrobial activity at 100 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 93361-66-1
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분자량 355.39
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화학식 C14H25N7O4
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SMILES
N=C(N)NCCC[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC1=CN=CN1
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Structure Classification
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Initial Source
Streptomyces roseoviridis
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Histargin Related Classifications
HY-122369 Related Classifications
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