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Cat. No.: HY-182712

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HPSE-IN-2

HPSE-IN-2 is a heparanase (HPSE) inhibitor with an IC₅₀ of 0.27 µM. HPSE-IN-2 reduces lung metastasis in mouse models. HPSE-IN-2 can be used for the research of melanoma.

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CAS No.: 53859-71-5
화학식: C₂₇H₂₀N₆O
분자량:444.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPSE-IN-2 Chemical Structure

CAS No.: 53859-71-5

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

HPSE-IN-2 is a heparanase (HPSE) inhibitor with an IC₅₀ of 0.27 µM. HPSE-IN-2 reduces lung metastasis in mouse models. HPSE-IN-2 can be used for the research of melanoma^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
B16	Inhibition	50 % Compound: 7a	Inhibition of proliferation on B16-BL6 melanoma cells at 100 uM Inhibition of proliferation on B16-BL6 melanoma cells at 100 uM	[PMID: 16246560]

In Vivo

HPSE-IN-2 (Compound 12a) (30 mg/kg; i.p.; single dose) inhibits B16 melanoma lung metastasis in C57 mice by approximately 50%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57 (experimental metastasis model via tail vein injection of B16 melanoma cells)^[1]
Dosage:

30 mg/kg
Administration:

i.p.; single dose
Result:

Inhibited lung metastasis by approximately 50% compared to the vehicle-treated group.

Chemical Information

CAS No. 53859-71-5
분자량 444.49
화학식 C₂₇H₂₀N₆O
SMILES

O=C(NC1=CC=C(C2=NC3=C(N2)C=CC=C3)C=C1)NC4=CC=C(C5=NC6=C(N5)C=CC=C6)C=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Miao HQ, et al. Development of heparanase inhibitors for anti-cancer therapy. Curr Med Chem. 2006;13(18):2101-2111. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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