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Cat. No.: HY-P1215

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HS024

Name: HS024
Brand: MedChemExpress
SKU: HY-P1215
Availability: PreOrder

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

HS024 is a peptide antagonist of melanocortin receptors with high affinity for the human melanocortin-4 receptor (MC4R). HS024 blocks α-MSH (HY-P0252)-induced cAMP accumulation and MC4 receptor signaling. HS024 induces dose-dependent feeding stimulation without affecting anxiety-related behavior or locomotor activity. HS024 can be used in research related to MC4 receptor-mediated diseases, such as eating disorders.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 212370-59-7
화학식: C₅₈H₇₉N₁₉O₁₀S₂
분자량:1266.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

HS024 Chemical Structure

CAS No.: 212370-59-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

MC4R

0.29 nM (Ki)

All Melanocortin Receptor Isoforms :

In Vitro

HS024 is a selective MC4 receptor antagonist with a K_i of 0.29 nM in COS-1 cells expressing the human MC4 receptor^[1].
HS024 blocks intracellular cAMP accumulation triggered by α-MSH (HY-P0252) in COS-1 cells expressing human MC1, MC3, MC4, and MC5 receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HS024 (0.1-1.0 nmol; i.c.v.; single injection on each test day; repeated every three days) induces a dose-dependent increase in food intake in free-feeding Wistar rats^[1].
HS024 (0.02-0.1 nmol; i.c.v.; single injection 20 min before testing) does not alter exploratory/locomotor activity in the elevated plus maze or open field^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (adult male, 330-380 g at time of surgery)^[1]
Dosage:

0.1 nmol, 0.3 nmol, 1.0 nmol
Administration:

i.c.v.; single injection per test day; repeated every third day in randomized order
Result:

Produced dose‑dependent orexigenic effects following intracerebroventricular administration.
Exhibited delayed onset: only 1 nmol stimulated food intake at 1 h; all doses elevated intake from 2‑4 h.
Achieved maximal 4‑fold feeding stimulation at 1 nmol, with 6‑8 g food consumed by rats within 4 h.
Triggered dose‑dependent food spillage, significant at 0.33 nmol and 1.0 nmol.
Showed no significant alteration in % spillage/CFI ratio.

Animal Model:

Wistar (adult male, 330-380 g at time of surgery)^[1]
Dosage:

0.02 nmol, 0.1 nmol
Administration:

i.c.v.; single injection 20 min before elevated plus-maze/open-field testing
Result:

Detected no overall anxiety‑related behavioral differences versus saline at 0.02 nmol and 0.1 nmol.
Observed comparable horizontal‑vertical open‑field locomotion across both doses.
Noted higher fecal‑boli counts solely for 0.02 nmol in elevated‑plus‑maze testing.
Found unaltered fecal‑boli output in open‑field assay for both doses.

Related Protocols :

Protocol for Open Field Test (OF)

Chemical Information

CAS No. 212370-59-7
분자량 1266.50
화학식 C₅₈H₇₉N₁₉O₁₀S₂
Sequence

Ac-Cys-{Nle}-Arg-His-{D-2Nal}-Arg-Trp-Gly-Cys-NH2 (Disulfide bridge:Cys1-Cys9)
Sequence Shortening

Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

J Neuroinflammation

A microglial LCN2-MC4R signaling axis drives silica-induced neuronal damage via C1q release. [Abstract]

2026 Jan 23;23(1):70. PMID: 41578331

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (287 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998 Dec;139(12):5006-14. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References

상품명:
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수량:
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HS024

Publications Citing Use of MedChemExpress (MCE) HS024

All Melanocortin Receptor Isoforms