HSK205
Based on 1 Customer Validation
HSK205 is a dual FLT3 and haspin inhibitor, with IC50 of 0.187 nM for FLT3. HSK205 has antitumor activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.01%
- CAS No.: 3022263-37-9
- 화학식: C26H24N6O
- 분자량:436.51
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Serine/Threonine Kinase Inhibitor Library
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Anti-Hematopathy Compound Library
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HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-14 | GI50 |
2.2 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MOLM-14 | GI50 |
22.4 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MOLM-14 | GI50 |
4.3 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MV4-11 | GI50 |
8.9 nM
Compound: 14; HSK205
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Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
Chemical Information
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CAS No. 3022263-37-9
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Appearance Solid
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분자량 436.51
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화학식 C26H24N6O
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Color Off-white to light yellow
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SMILES
O=C(NCC1=NC(C)=CN1)C(C=C2)=CC=C2C(C3=C4CCCC3)=NC5=C4C(C=NN6)=C6C=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 4.17 mg/mL (9.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2909 mL | 11.4545 mL | 22.9090 mL | 57.2725 mL |
| 5 mM | 0.4582 mL | 2.2909 mL | 4.5818 mL | 11.4545 mL |
HSK205 Related Classifications
HY-155341 Related Classifications
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